Antioxidant, antihemolysis, and retinoprotective potentials of bioactive lipidiccompounds from wild shrimp (Litopenaeus stylirostris) muscle

Abstract

The oxidative stress damage on cells is an example of roles in the pathogenesis of differentdegenerative diseases and the search of compounds that can slow this oxidation is continuous.The aim of this work was to obtain bioactive fractions from wild shrimp (Litopenaeus stylirostris)muscle, in order to evaluate their protective capacity and chemo-structurally characterize them.ABTS and DPPH, and FRAP assays suggested that bioactive fractions possess free radical-scavengingcapacity, and reducing power, respectively. An inhibitory effect observed on AAPH-induced hemo-lysis and results from an H2O 2-derived radicals-scavenging assay (retinoprotective) suggest thatthese fractions can exert their protective activity in human cells. UV–Vis, fluorescence, 13C-, 1H-NMR,and ESI-MS studies performed on the most bioactive fraction, suggests that their main componentsare eicosapentaenoic acid, dioctyl phthalate, and a possibly novel indolocarbazole alkaloid deriva-tive. These results suggest that these compounds are good candidates to further investigations aspossible chemoprotective agents.