Genetic analysis of 12 X-chromosomal STRs an autochthonous population of Southeast Spain

Abstract

The analysis of X-chromosomal short tandem repeats (STRs) is a valuable tool as well as a useful complement to the study of autosomal and Y chromosome STRs in complex kinship cases due to the particular inheritance of the X chromosome. Currently it is necessary to expand the study of a greater number of X-STRs, and know their population characteristics, for better forensic purposes. The allelic frequencies and further population forensic genetic parameters were studied in 12 X-Chromosome STRs loci included in the InvestigatorTM Argus X-12 Kit. Data has been obtained from 121 unrelated autochthonous subjects, 59 females, and 62 males an area of southeast Spain, with relevant demographic and historical characteristics. Allele frequencies for each marker were determined, and the most frequent alleles observed have been: DXS10103 (allele 19), DXS8378 (allele 10), DXS10101 (allele 30.2), DXS10134 (allele 36), DXS10074 (allele 17), DXS7132 (allele 14), DXS10135 (allele 21), DXS7423 (allele 15), DXS10146 (allele 29), DXS10079 (allele 20), DXSHPRTB (allele 12), and DXS10148 (allele 24.1). The obtained data will contribute to further progress in the studies on chromosome X in Spain.