Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/11000/37577

Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats


Vista previa

Ver/Abrir:
 Pohjanvirta.pdf

1,75 MB
Adobe PDF
Compartir:
Título :
Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats
Autor :
Pohjanvirta, Raimo  
Karppinen, Ira
Galbán-Velázquez, Suylen
Esteban Mozo, Javier
Håkansson, Helen
Sankari, Satu
Lindén, Jere  
Editor :
Elsevier
Departamento:
Departamentos de la UMH::Biología Aplicada
Fecha de publicación:
2021-09
URI :
https://hdl.handle.net/11000/37577
Resumen :
The physiological functions of the aryl hydrocarbon receptor (AHR) are only beginning to unfold. Studies in wildtype and AHR knockout (AHRKO) mice have recently disclosed that AHR activity is required for obesity and steatohepatitis to develop when mice are fed with a high-fat diet (HFD). In addition, a line of AHRKO mouse has been reported to accumulate retinoids in the liver. Whether these are universal manifestations across species related to AHR activity level is not known yet. Therefore, we here subjected wildtype and AHRKO male rats (on Sprague-Dawley background) to HFD feeding coupled with free access to 10% sucrose solution and water; controls received a standard diet and water. Although the HFD-fed rats consumed more energy throughout the 24-week feeding regimen, they did not get overweight. However, relative weights of the brown and epididymal adipose tissues were elevated in HFDfed rats, while that of the liver was lower in AHRKO than wildtype rats. Moreover, the four groups exhibited diet- or genotype-dependent differences in biochemical variables, some of which suggested marked dissimilarities from AHRKO mice. Expression of pro- and anti-inflammatory genes was induced in livers of HFD-fed AHRKO rats, but histologically they did not differ from others. HFD reduced the hepatic concentrations of retinyl palmitate, 9-cis-4- oxo-13,14-dihydroretinoic acid and (suggestively) retinol, whereas AHR status had no effect. Hence, the background strain/line of AHRKO rat is resistant to diet-induced obesity, and AHR does not modulate this or liver retinoid concentrations. Yet, subtle AHR-dependent differences in energy balance-related factors exist despite similar weight development.
Palabras clave/Materias:
Aryl hydrocarbon receptor
Genetically modified organisms
High-fat diet
Diet-induced obesity
Energy balance
Retinoids
Área de conocimiento :
CDU: Ciencias puras y naturales: Biología
Tipo de documento :
info:eu-repo/semantics/article
Derechos de acceso:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.1016/j.jnutbio.2021.108762
Publicado en:
The Journal of Nutritional Biochemistry, Volume 95, September 2021, 108762
Aparece en las colecciones:
Artículos Biología Aplicada



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.