Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/11000/35265
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorRamos Rincón, José Manuel-
dc.contributor.authorHerrera García, Cristian-
dc.contributor.authorSilva-Ortega, Sandra-
dc.contributor.authorPortilla Tamarit, Julia-
dc.contributor.authorAlenda, Cristina-
dc.contributor.authorJaime-Sánchez, Francisco-
dc.contributor.authorArenas Jiménez, Juan José-
dc.contributor.authorFornés Riera, Francisca Eugenia-
dc.contributor.authorScholz, Alexander-
dc.contributor.authorEscribano, Isabel-
dc.contributor.authorPedrero-Castillo, Victor-
dc.contributor.authorMuñoz-Miguelsanz, Carlos-
dc.contributor.authorOrts-Linares, Pedro-
dc.contributor.authorMartí Pastor, Ana-
dc.contributor.authorAmo Lozano, Antonio-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.date.accessioned2025-01-24T13:27:15Z-
dc.date.available2025-01-24T13:27:15Z-
dc.date.created2022-07-
dc.identifier.citationFrontiers in Medicine. 2022 Jul 7:9:874307es_ES
dc.identifier.issn2296-858X-
dc.identifier.urihttps://hdl.handle.net/11000/35265-
dc.description.abstractBackground: Autopsies can shed light on the pathogenesis of new and emerging diseases. Aim: To describe needle core necropsy findings of the lung, heart, and liver in decedents with COVID-19. Material: Cross-sectional study of needle core necropsies in patients who died with virologically confirmed COVID-19. Histopathological analyses were performed, and clinical data and patient course evaluated. Results: Chest core necropsies were performed in 71 decedents with a median age of 81 years (range 52-97); 47 (65.3%) were men. The median interval from symptoms onset to death was 17.5 days (range 1-84). Samples of lung (n = 62, 87.3%), heart (n = 48, 67.6%) and liver (n = 39, 54.9%) were obtained. Fifty-one lung samples (82.3%) were abnormal: 19 (30.6%) showed proliferative diffuse alveolar damage (DAD), 12 (19.4%) presented exudative DAD, and 10 (16.1%) exhibited proliferative plus exudative DAD. Of the 46 lung samples tested for SARS-CoV-19 by RT-PCR, 39 (84.8%) were positive. DAD was associated with premortem values of lactate dehydrogenase of 400 U/L or higher [adjusted odds ratio (AOR) 21.73; 95% confidence interval (CI) 3.22-146] and treatment with tocilizumab (AOR 6.91; 95% CI 1.14-41.7). Proliferative DAD was associated with an onset-to-death interval of over 15 days (AOR 7.85, 95% CI 1.29-47.80). Twenty-three of the 48 (47.9%) heart samples were abnormal: all showed fiber hypertrophy, while 9 (18.8%) presented fibrosis. Of the liver samples, 29/39 (74.4%) were abnormal, due to steatosis (n = 12, 30.8%), cholestasis (n = 6, 15.4%) and lobular central necrosis (n = 5, 12.8%). Conclusion: Proliferative DAD was the main finding on lung core needle necropsy in people who died from COVID-19; this finding was related to a longer disease course. Changes in the liver and heart were common.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent15es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectautopsyes_ES
dc.subjectpathologyes_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectcoronaviruses_ES
dc.subjectCOVID-19es_ES
dc.titlePathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Coursees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversion10.3389/fmed.2022.874307es_ES
Aparece en las colecciones:
Artículos Patología y Cirugía


Vista previa

Ver/Abrir:
 Pathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies. Correlation With Clinical Presentation and Disease Course.pdf

4,93 MB
Adobe PDF
Compartir:


Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.