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dc.contributor.authorRuiz Picazo, Alejandro-
dc.contributor.authorGonzalez-Alvarez, Marta-
dc.contributor.authorGonzalez-Alvarez, Isabel-
dc.contributor.authorBermejo, Marival-
dc.contributor.otherDepartamentos de la UMH::Ingenieríaes_ES
dc.date.accessioned2025-01-22T12:12:38Z-
dc.date.available2025-01-22T12:12:38Z-
dc.date.created2020-05-
dc.identifier.citationMolecular Pharmaceutics, 17/Issue 7es_ES
dc.identifier.issn1543-8392-
dc.identifier.issn1543-8384-
dc.identifier.urihttps://hdl.handle.net/11000/35148-
dc.description.abstractTheaimof thepresentpaper is tostudytheeffectofcommonexcipientsonthepermeabilityofatenolol (asdrug absorbedmainlybypassivediffusion)andrhodamine(asP-glycoproteinsubstrate).Theapparentpermeabilitywasmeasuredbyan insituperfusionmethod inWistar ratsusing theclosed loopDoluisio’smethod. Permeabilityvalueswerecharacterized inthe absence andpresenceof 18commonlyusedexcipients. Excipient concentrationswere selectedbasedon the amounts inoral immediate releasedosage forms,which failedthe testduring thehumanbioequivalence studies.Atenololwas studiedwithand withoutexcipients inthewholesmall intestine,whereasrhodaminewastestedinthreedifferent intestinal segmentstoaccount for thedifferential expressionof P-glycoprotein, and itwas further on tested in the ileum, in thepresenceof excipients. Atenolol presentedhigherpermeabilityvalueswhenitwasadministeredwithcolloidal silica, croscarmellose,hydroxypropylmethylcellulose (HPMC),magnesiumstearate,MgCO3, poly(ethyleneglycol)400, poly(vinylpyrrolidone), sorbitol, starch, andTiO2 rhodamine showedhigherpermeabilityvalueswhenitwasadministeredwithcroscarmelloseandHPMC.Ontheonehand, themechanismsof actionwerenotdiscerniblewiththeproposedexperiments.Ontheotherhand, commercial formulationsdonotpresentasingle excipientbutseveral,whichcancounteracttheireffects.Theinsituperfusiontechniquecanbeusefulforapreliminaryscreeningand riskanalysis,whilethe invivopharmacokineticresultswouldbeneededtodefineconclusiveeffects.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent9es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectpermeabilityes_ES
dc.subjectexcipientes_ES
dc.subjectpassivediffusiones_ES
dc.subjectP-glycoproteines_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnologíaes_ES
dc.titleEffect of Common Excipients on Intestinal Drug Absorption in Wistar Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://dx.doi.org/10.1021/acs.molpharmaceut.0c00023es_ES
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