Título : A nanoencapsulated Ir(III)-phthalocyanine conjugate as a promising photodynamic therapy anticancer agent |
Autor : Bonelli, Joaquin Ortega-Forte, Enrique Vigueras, Gloria Follana-Berná, Jorge Ashoo, Pezhman Abad-Montero, Diego Isidro, Neus López-Corrales, Marta Hernández, Adrián Ortiz, Javier Izquierdo García, Eduardo Bosch, Manel Rocas, Josep Sastre-Santos, Ángela Ruiz, José Marchán, Vicente |
Editor : American Chemical Society |
Departamento: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Fecha de publicación: 2024-07-23 |
URI : https://hdl.handle.net/11000/33851 |
Resumen :
Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (Ir-ZnPc) as a novel photosensitizer for high-efficiency synergistic PDT treatment that takes advantage of the long-wavelength excitation and near infrared (NIR) emission of the phthalocyanine scaffold and the known photostability and high phototoxicity of cyclometalated Ir(III) complexes. In order to increase water solubility and cell membrane permeability, the conjugate and parent zinc phthalocyanine (ZnPc) were encapsulated in amphoteric redox-responsive polyurethane-polyurea hybrid nanocapsules (Ir-ZnPc-NCs and ZnPc-NCs, respectively). Photobiological evaluations revealed that the encapsulated Ir-ZnPc conjugate achieved high photocytotoxicity in both normoxic and hypoxic conditions under 630 nm light irradiation, which can be attributed to dual Type I and Type II reactive oxygen species (ROS) photogeneration. Interestingly, PDT treatments with Ir-ZnPc-NCs and ZnPc-NCs significantly inhibited the growth of three-dimensional (3D) multicellular tumor spheroids. Overall, the nanoencapsulation of Zn phthalocyanines conjugated to cyclometalated Ir(III) complexes provides a new strategy for obtaining photostable and biocompatible red-light-activated nano-PDT agents with efficient performance under challenging hypoxic environments, thus offering new therapeutic opportunities for cancer treatment.
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Palabras clave/Materias: zinc phthalocyanines cyclometalated iridium(III) complexes photodynamic therapy nanoencapsulation anticancer agents drug design photosensitizer hypoxia nanoencapsulation |
Área de conocimiento : CDU: Ciencias puras y naturales: Química |
Tipo de documento : info:eu-repo/semantics/article |
Derechos de acceso: info:eu-repo/semantics/openAccess |
DOI : https://doi.org/10.1021/acsami.4c05181 |
Aparece en las colecciones: Artículos Farmacología, Pediatría y Química Orgánica
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