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dc.contributor.authorLatour-Perez, Jaime-
dc.contributor.authorGómez-Tello, Vicente-
dc.contributor.authorFuset-Cabanes, María Paz-
dc.contributor.authorde Miguel Balsa, Eva-
dc.contributor.authordel Nogal Sáez, Frutos-
dc.contributor.authorCoves Orts, Francisco Javier-
dc.contributor.authorMartín Rodríguez, Carmen-
dc.contributor.authorPino-Izquierdo, Karel-
dc.contributor.authorPavía Pesquera, María de la Concepción-
dc.contributor.authorMontón Rodríguez, Antonio José-
dc.contributor.authorARIAM-SEMICYUC Group-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-08T11:41:11Z-
dc.date.available2024-02-08T11:41:11Z-
dc.date.created2013-
dc.identifier.citationJournal of Cardiovascular Medicine (Hagerstown) . 2013 Nov;14(11):799-806es_ES
dc.identifier.issn1558-2035-
dc.identifier.issn1558-2027-
dc.identifier.urihttps://hdl.handle.net/11000/31284-
dc.description.abstractAims: Several reports have suggested that nitrates limit acute ischaemic damage by a mechanism similar to preconditioning. This study aims to evaluate the effect of chronic oral nitrates on the clinical presentation and short-term outcomes of patients admitted with acute coronary syndrome (ACS).Methods: A retrospective cohort study was conducted in patients with ACS admitted to 62 acute care units from 2010 to 2011. A propensity score-matched samples analysis was performed.Results: We analysed 3171 consecutive patients, of whom 298 (9.4%) were chronically treated with nitrates. Patients previously treated with nitrates had higher comorbidity and disease severity at admission, lower prevalence of ACS with ST elevation, lower troponin elevation, higher prevalence of initial Killip class 2-4 and higher hospital mortality. The propensity score-matched analysis confirmed that previous use of nitrates is independently associated with a lower prevalence of ST-elevation ACS [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.36-0.78; P = 0.0014] and a lower troponin elevation (OR 0.61, 95% CI 0.41-0.92) but not with Killip class on admission (OR 1.18, 95% CI 0.83-1.67, P = 0.3697) or mortality (OR 0.71, 95% CI 0.37-1.38, P = 0.3196).Conclusion: The results support the hypothesis that nitrates have a protective effect on acute ischaemic injury.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent8es_ES
dc.language.isoenges_ES
dc.publisherItalian Federation of Cardiologyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleClinical presentation of acute coronary syndrome in patients previously treated with nitrateses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.2459/JCM.0b013e32835f4df1es_ES
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