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dc.contributor.authorMoreno-Perez, Oscar-
dc.contributor.authorReyes-Garcia, Rebeca-
dc.contributor.authorMuñoz-Torres, Manuel-
dc.contributor.authorMerino, Esperanza-
dc.contributor.authorBoix, Vicente-
dc.contributor.authorReus, Sergio-
dc.contributor.authorGiner, Livia-
dc.contributor.authorALFAYATE-
dc.contributor.authorGarcía Fontana, Beatriz-
dc.contributor.authorSanchez-Paya, Jose-
dc.contributor.authorPicó , Antonio-
dc.contributor.authorPortilla, Joaquín-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-07T10:18:10Z-
dc.date.available2024-02-07T10:18:10Z-
dc.date.created2018-06-24-
dc.identifier.citationClin Endocrinol (Oxf). 2018 Oct;89(4):414-423es_ES
dc.identifier.issn1365-2265-
dc.identifier.issn0300-0664-
dc.identifier.urihttps://hdl.handle.net/11000/31205-
dc.description.abstractObjective: HIV infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may influence insulin homeostasis, nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Our objective was to evaluate the relationships between serum irisin, insulin homeostasis, NAFLD and subclinical atherosclerosis in HIV-infected males. Design: Cross-sectional study in a cohort of HIV-infected patients. Patients: Inclusion criteria: men older than 18 years; antiretroviral therapy (ART) -naïve or on effective ART (<50 HIV-1 RNA copies/mL) without changes in the previous 6 months; no diabetes or hepatitis C. Measurements: Irisin was measured by enzymatic immunoassay (Phoenix Pharmaceuticals), insulin sensitivity by homeostasis model assessment of insulin resistance (HOMA-IR), as well as the 2-hour continuous infusion of glucose with model assessment (CIGMA-HOMA). Hepatic steatosis was measured by 1-H magnetic resonance spectroscopy, subclinical atherosclerosis by evaluation of carotid intima-media thickness (C-IMT), measured by Ultrasonography. Results: Eight nine men (age 42.0 ± 8.3 years, duration of HIV infection 7.9 ± 5.6 years, CD4 count 547 ± 279 cells/mL) were included. Circulating irisin was positively related to HOMA-IR and CIGMA-HOMA, hepatic triglyceride content, and to VAT/SAT ratio. Higher irisin concentrations were associated with higher C-IMT, although this association did not persist in multivariate analysis. Lipodystrophy and a higher baseline PAI-1 concentration were independently associated with C-IMT. Conclusions: In male HIV patients without diabetes, higher irisin concentrations are positively associated with insulin resistance, NAFLD and subclinical atherosclerosis. However, waist-hip- ratio is the main determinant of insulin resistance, and PAI-1 and lipodystrophy were the strongest determinants of IMT in this population.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent10es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcardiovasculares_ES
dc.subjectcarotid intima-media thicknesses_ES
dc.subjectHIVes_ES
dc.subjectinsulin homeostasises_ES
dc.subjectirisines_ES
dc.subjectnonalcoholic fatty liver diseasees_ES
dc.subjectsubclinical atherosclerosises_ES
dc.titleHigh Irisin levels in nondiabetic HIV-infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/cen.13800es_ES
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