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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Company Devesa, Verónica | - |
dc.contributor.author | Andreu Cervera, Abraham | - |
dc.contributor.author | Madrigal Verdú, María del Pilar | - |
dc.contributor.author | Andrés Bayón, Belén | - |
dc.contributor.author | Almagro García, Francisca de Paula | - |
dc.contributor.author | Chedotal, Alain | - |
dc.contributor.author | López Bendito, Guillermina | - |
dc.contributor.author | Martínez Pérez, Salvador | - |
dc.contributor.author | Echevarría Aza, Diego | - |
dc.contributor.author | Moreno Bravo, Juan Antonio | - |
dc.contributor.author | de Puelles Martínez de La Torre, Eduardo | - |
dc.contributor.other | Departamentos de la UMH::Patología y Cirugía | es_ES |
dc.contributor.other | Departamentos de la UMH::Histología y Anatomía | es_ES |
dc.contributor.other | Instituto de Neurociencias | es_ES |
dc.date.accessioned | 2024-02-06T17:13:59Z | - |
dc.date.available | 2024-02-06T17:13:59Z | - |
dc.date.created | 2021-06 | - |
dc.identifier.citation | Frontiers in cell and developmental biology 2021 Jun 8:9:682067 | es_ES |
dc.identifier.issn | Electronic: 2296-634X | - |
dc.identifier.uri | https://hdl.handle.net/11000/31168 | - |
dc.description.abstract | The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organization of habenular circuitry requires complex molecular programs to control the wiring of the habenula during development. However, the mechanisms guiding the habenular axons toward their targets remain mostly unknown. Here, we demonstrate the role of the mesodiencephalic dopaminergic neurons (substantia nigra pars compacta and ventral tegmental area) as an intermediate target for the correct medial habenular axons navigation along the anteroposterior axis. These neuronal populations are distributed along the anteroposterior trajectory of these axons in the mesodiencephalic basal plate. Using in vitro and in vivo experiments, we determined that this navigation is the result of netrin 1 attraction generated by the mesodiencephalic dopaminergic neurons. This attraction is mediated by the receptor deleted in colorectal cancer (DCC), which is strongly expressed in the medial habenular axons. The increment in our knowledge on the fasciculus retroflexus trajectory guidance mechanisms opens the possibility of analyzing if its alteration in mental health patients could account for some of their symptoms | es_ES |
dc.format | application/pdf | es_ES |
dc.format.extent | 16 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media [Commercial Publisher] | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DCC | es_ES |
dc.subject | axon guidance | es_ES |
dc.subject | fasciculus retroflexus | es_ES |
dc.subject | habenula | es_ES |
dc.subject | netrin 1 | es_ES |
dc.subject | substantia nigra pars compacta | es_ES |
dc.subject | ventral tegmental area | es_ES |
dc.title | Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fcell.2021.682067 | es_ES |
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