Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31133
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLeón, Rafael-
dc.contributor.authorReus Bañuls, Sergio Javier-
dc.contributor.authorLópez, Nicolás-
dc.contributor.authorPortilla, Irene-
dc.contributor.authorSánchez Payá, José-
dc.contributor.authorGiner, Livia-
dc.contributor.authorBoix Martínez, Vicente-
dc.contributor.authorMerino de Lucas, Esperanza-
dc.contributor.authorTorrús Tendero, Diego-
dc.contributor.authorMoreno Pérez, Óscar-
dc.contributor.authorPortilla Sogorb, Joaquín-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.contributor.otherDepartamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecologíaes_ES
dc.date.accessioned2024-02-06T06:41:52Z-
dc.date.available2024-02-06T06:41:52Z-
dc.date.created2017-08-
dc.identifier.citationEuropean Journal of Clinical Investigation 2017 Aug;47(8):591-599es_ES
dc.identifier.issn0014-2972-
dc.identifier.issn1365-2362-
dc.identifier.urihttps://hdl.handle.net/11000/31133-
dc.description.abstractBackground Pathogenesis of atherosclerosis is complex, and differences between HIV-infected patients and general population cannot be completely explained by the higher prevalence of traditional cardiovascular risk factors. We aimed to analyse the association between inflammation and subclinical atherosclerosis in HIV patients with low Framingham risk score. Materials and methods Case–control study. Setting: Outpatient Infectious Diseases clinic in a university hospital. Subjects: HIV-1-infected patients aged > 35 years receiving antiretroviral treatment with viral load < 50 copies/mL and Framingham risk score < 10%. Exclusion criteria: inflammatory diseases; dyslipidaemia requiring statins; smoking > 5 cigarettes/day; diabetes; hypertension; vascular diseases. Main outcome: subclinical atherosclerosis determined by ultrasonography: common carotid intima-media thickness greater than 0 8 mm or carotid plaque presence. Explanatory variables: ribosomal bacterial DNA (rDNA), sCD14, interleukin-6 (IL-6) and TNF-a. Results Eighty-four patients were included, 75% male, mean age 42 years and mean CD4+ cells 657 215/ mm3. Median Framingham risk score was 1% at 10 years (percentile 25–75: 0 5–4%). Eighteen patients (21%) had subclinical atherosclerosis; the associated factors were older age (P = 0 001), waist–hip ratio (P = 0 01), time from HIV diagnosis (P = 0 02), rDNA (P = 0 04) and IL-6 (P = 0 01). In multivariate analysis, OR for subclinical atherosclerosis was 7 (95% CI, 1.3–40, P = 0.02) and 9 (95% CI, 1.0–85, P = 0.04) for patients older than 44 years and IL-6 > 6 6 pg/mL, respectively. Conclusions Well-controlled HIV patients with low Framingham risk score have a high prevalence of subclinical carotid atherosclerosis, and the main risk factors are age and inflammation. These patients are not receiving primary prophylaxis for cardiovascular events according to current guidelines.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent9es_ES
dc.language.isoenges_ES
dc.publisherWiley [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIVes_ES
dc.subjectinflammationes_ES
dc.subjectintima-media thicknesses_ES
dc.subjectmicrobial translocationes_ES
dc.subjectsubclinical atherosclerosises_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermeríaes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleSubclinical atherosclerosis in low Framingham risk HIV patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/eci.12780es_ES
Appears in Collections:
Artículos Medicina Clínica


no-thumbnailView/Open:

 Subclinical atherosclerosis in low Framingham risk HIV patients.pdf



167,55 kB
Adobe PDF
Share:


Creative Commons ???jsp.display-item.text9???