Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31115
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dc.contributor.authorGracia-Sancho, Jordi-
dc.contributor.authorCaparrós, Esther-
dc.contributor.authorFernández-Iglesias, Anabel-
dc.contributor.authorFrancés, Rubén-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T18:15:27Z-
dc.date.available2024-02-05T18:15:27Z-
dc.date.created2021-
dc.identifier.citationNature Reviews Gastroenterology & Hepatology . 2021 Jun;18(6):411-431es_ES
dc.identifier.issn1759-5053-
dc.identifier.urihttps://hdl.handle.net/11000/31115-
dc.description.abstractLiver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike other capillaries, they lack an organized basement membrane and have cytoplasm that is penetrated by open fenestrae, making the hepatic microvascular endothelium discontinuous. LSECs have essential roles in the maintenance of hepatic homeostasis, including regulation of the vascular tone, inflammation and thrombosis, and they are essential for control of the hepatic immune response. On a background of acute or chronic liver injury, LSECs modify their phenotype and negatively affect neighbouring cells and liver disease pathophysiology. This Review describes the main functions and phenotypic dysregulations of LSECs in liver diseases, specifically in the context of acute injury (ischaemia-reperfusion injury, drug-induced liver injury and bacterial and viral infection), chronic liver disease (metabolism-associated liver disease, alcoholic steatohepatitis and chronic hepatotoxic injury) and hepatocellular carcinoma, and provides a comprehensive update of the role of LSECs as therapeutic targets for liver disease. Finally, we discuss the open questions in the field of LSEC pathobiology and future avenues of research.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent21es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleRole of liver sinusoidal endothelial cells in liver diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41575-020-00411-3es_ES
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