Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31105
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dc.contributor.authorGómez-Hurtado, Isabel-
dc.contributor.authorGallego-Durán, Rocío-
dc.contributor.authorZapater, Pedro-
dc.contributor.authorAmpuero, Javier-
dc.contributor.authorAller, Rocío-
dc.contributor.authorCrespo, Javier-
dc.contributor.authorArias-Loste, María Teresa-
dc.contributor.authorGarcía-Monzón, Carmelo-
dc.contributor.authorBellot, Pablo-
dc.contributor.authorGonzález-Rodríguez, Águeda-
dc.contributor.authorJuanola, Oriol-
dc.contributor.authorRomero Gómez, Manuel-
dc.contributor.authorFrancés, Rubén-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T17:57:16Z-
dc.date.available2024-02-05T17:57:16Z-
dc.date.created2020-
dc.identifier.citationLiver International . 2020 Sep;40(9):2182-2193es_ES
dc.identifier.issn1478-3231-
dc.identifier.urihttps://hdl.handle.net/11000/31105-
dc.description.abstractBackground & aims: Low-grade systemic inflammation is a crucial landmark in NAFLD favouring disease progression and comorbidities. We evaluated the input of circulating bacterial antigens on systemic markers of inflammation in NAFLD patients.Patients & methods: Multicenter cross-sectional study including consecutive patients with biopsy-proven NAFLD. Demographic, metabolic and fibrosis-related variables were collected. Circulating bacterial antigens were quantified in blood. Toll-like receptor SNPs were genotyped. Serum cytokine levels were evaluated. Peripheral blood mononuclear cell response to bacterial antigens was evaluated in vitro.Results: Three hundred and fifteen patients from five Spanish hospitals were distributed by BMI. At least, one bacterial antigenic type was found in 66 patients with BMI < 30 (63.4%) and 163 patients with BMI > 30 (77.3%) (P = .014). HOMA-IR was significantly higher in the presence of circulating antigens among patients with BMI < 30. NASH and significant fibrosis in non-obese patients were more frequent in the presence of at least two circulating antigenic types. Allelic frequencies of TLR variants were similar to controls and did not affect clinical or laboratory parameters. Pro-inflammatory cytokines were significantly increased in patients with bacterial antigens, regardless of BMI. TLR gene and protein expression levels were significantly increased in PBMCs from patients with bacterial antigens. Antigen concentrations independently influenced TNF-α and IL-6, in both BMI subgroups of patients. Age independently influenced TNF-α and IL-6 in non-obese patients, and TNF-α in obese patients.Conclusion: Serum circulating bacterial antigens as well as age were BMI-independent factors related to increased systemic inflammation in NAFLD and provides insight on the multifaceted sources of inflammation in these patients.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNAFLDes_ES
dc.subjectaginges_ES
dc.subjectbacterial translocationes_ES
dc.subjectcytokineses_ES
dc.subjectinsulin resistancees_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleBacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/liv.14571es_ES
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