Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31089
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dc.contributor.authorSánchez Ortiga, Ruth-
dc.contributor.authorSánchez-Tejada, Laura-
dc.contributor.authorMoreno-Perez, Oscar-
dc.contributor.authorRiesgo, Pedro-
dc.contributor.authorNiveiro, Maria-
dc.contributor.authorPicó Alfonso, Antonio M.-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T17:48:24Z-
dc.date.available2024-02-05T17:48:24Z-
dc.date.created2012-
dc.identifier.citationPituitary . 2013 Sep;16(3):370-7es_ES
dc.identifier.issn1573-7403-
dc.identifier.urihttps://hdl.handle.net/11000/31089-
dc.description.abstractSome pituitary adenomas (PA) demonstrate aggressive behavior with local invasion and recurrences. Angiogenesis is regarded as an essential step in the formation of solid tumors. The aim of this study is to find out whether angiogenic factors may have information about the aggressiveness of PA that could be useful in determining the frequency of follow-up and whether adjuvant therapy is necessary. In this retrospective descriptive study, we evaluated vascular endothelial growth factors (VEGF) and VEGF receptor (KDR) mRNA expression by RT-PCR analysis on 46 human PA samples. Clinical data, histological subtype and radiologic characteristics were studied to determine the associations between the variables and the pre-operative behavior of the tumor. In addition, we monitored 12 patients without adjuvant post-operative therapies over 46 months after surgery, determining progression of tumor remnants and its association with these markers. VEGF expression correlates with KDR expression (r = 0.40, p = 0.006). VEGF demonstrates different expression between histological subtypes (p = 0.036). The extension at magnetic resonance imaging showed that VEGF expression was related to suprasellar extension (p = 0.007), being expressed more on tumors with extrasellar growth than intrasellar ones (p = 0.008). Our results demonstrate a 27.5 times increased risk of extrasellar growth when VEGF expression exceeds 0.222 normalized copy number (NCN) (p = 0.002). Likewise, tumors with KDR greater than 0.750 NCN had less recurrence-free survival time (p = 0.032). Our results suggest that the expression of VEGF and its receptor could be a marker for poor outcome after partial tumor resection. These data should be considered in future studies evaluating angiogenic factors as therapeutic targets in patients with PA.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent8es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPituitary adenomaes_ES
dc.subjectVEGFes_ES
dc.subjectKDR Tyrosine kinasees_ES
dc.subjectRecurrencees_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleOver-expression of vascular endothelial growth factor in pituitary adenomas is associated with extrasellar growth and recurrencees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s11102-012-0434-4es_ES
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