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Risk factors for sexual and erectile dysfunction in HIV-infected men: the role of protease inhibitors


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Título :
Risk factors for sexual and erectile dysfunction in HIV-infected men: the role of protease inhibitors
Autor :
Moreno-Pérez, Oscar
Escoín, Corina
Serna-Candel, Carmen  
Picó, Antonio
ALFAYATE
Merino, Esperanza
Reus, Sergio
Boix, Vicente
Sánchez-Paya, José
Portilla, Joaquin  
Editor :
Wolters Kluwer Health
Departamento:
Departamentos de la UMH::Medicina Clínica
Fecha de publicación:
2010
URI :
https://hdl.handle.net/11000/31088
Resumen :
Objectives: To determine the prevalence of erectile dysfunction in a cohort of HIV-infected men in a stable clinical state, the effect of exposure to antiretroviral therapy on sexual dysfunction and to identify the risk factors.Design: This is a cross-sectional, observational study.Methods: HIV-infected men without hepatitis C virus coinfection were included if they were antiretroviral therapy-naive (naive group), on current treatment with an enhanced protease inhibitor (protease inhibitor group) or on current treatment with two to three nucleoside reverse transcriptase inhibitors along with one nonnucleoside reverse transcriptase inhibitor and never having received treatment with protease inhibitor (nonnucleoside reverse transcriptase inhibitor group). Erectile dysfunction was defined as an ejection fraction of 25 or less (International Index of Erectile Function-15).Results: Ninety patients were included, with an age of 42 +/- 8.2 years and CD4 cell count of 465 cells/microl [P25-75 361-676]: 18.9% in Centers for Disease Control and Prevention class C and 72.2% with undetectable viral load. Seventy-six patients (84.4%) were receiving antiretroviral therapy, 39 (43.3%) in the protease inhibitor group. The prevalence of lipodystrophy was 31.5%. Forty-seven (53.4%) patients had an erectile dysfunction. Multivariate logistic regression analysis confirmed that there was an independent association between the patients' age (per decade; odds ratio 2.2, 95% confidence interval 1.04-4.5, P = 0.04) and greater duration of exposure to protease inhibitor (per year; odds ratio 1.6, 95% confidence interval 1.12-2.4, P = 0.01). Older age, depression and lipodystrophy, combined with the duration of exposure to protease inhibitor, determined a lower score on various sexual dysfunction domains (P < 0.05).Conclusion: There is a high prevalence of erectile dysfunction in HIV-infected men, with age and the duration of exposure to protease inhibitor being the only identifiable risk factors.
Palabras clave/Materias:
antiretroviral therapy
erectile dysfunction
HIV
prevalence
risk factors
sexual dysfunction
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina: Patología. Medicina clínica. Oncología
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/closedAccess
DOI :
https://doi.org/10.1097/QAD.0b013e328334444b
Aparece en las colecciones:
Artículos Medicina Clínica



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