Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30808
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dc.contributor.authorMicol-Ponce, Rosa-
dc.contributor.authorSarmiento, Raquel-
dc.contributor.authorRuiz-Bayón, Alejandro-
dc.contributor.authorMontacié, Charlotte-
dc.contributor.authorSáez-Vázquez, Julio-
dc.contributor.authorPonce, María Rosa-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-01-26T22:54:41Z-
dc.date.available2024-01-26T22:54:41Z-
dc.date.created2018-11-
dc.identifier.citationThe Plant Cell, Vol. 30: 2855–2872, November 2018es_ES
dc.identifier.issn1532-298X-
dc.identifier.issn1040-4651-
dc.identifier.urihttps://hdl.handle.net/11000/30808-
dc.description.abstractRibosome biogenesis is fundamental to growth and development in eukaryotes and is linked to human diseases and cancer. Arabidopsis thaliana MORPHOLOGY OF ARGONAUTE1-52 SUPPRESSED 2 (MAS2) participates in splicing and 45S ribosomal DNA (rDNA) expression. In a screen for MAS2 interactors, we identified RIBOSOMAL RNA PROCESSING 7 (RRP7), an ortholog of yeast rRNA processing protein 7 (Rrp7), which is required for 18S ribosomal RNA (rRNA) maturation. Arabidopsis rrp7 mutants exhibit a pleiotropic phenotype including slow growth, altered shoot phyllotaxy, aberrant venation in lateral organs, partial infertility, and abscisic acid hypersensitivity in seedlings. In Arabidopsis, RRP7 localizes mainly to the nucleolus, the site of the 45S rDNA transcription that produces a 45S pre-rRNA primary transcript, precursor of the 25S, 18S and 5.8S rRNAs. Lack of RRP7 function perturbs 18S rRNA maturation, causes nucleolar hypertrophy, and results in an increased 25S/18S rRNA ratio. Arabidopsis contains hundreds of 45S rDNA genes whose expression is epigenetically regulated, and deregulated, in rrp7 mutants. Double mutant analysis revealed synergistic interactions between RRP7 alleles and alleles of MAS2, NUCLEOLIN1 (NUC1), and HISTONE DEACETYLASE 6 (HDA6), which encode epigenetic regulators of 45S rDNA transcription. Our results reveal the evolutionarily conserved but divergent roles of RRP7 as a ribosome biogenesis factor.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent18es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationGenéticaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleArabidopsis RIBOSOMAL RNA PROCESSING7 Is Required for 18S rRNA Maturationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1105/tpc.18.00245es_ES
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