Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30472
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dc.contributor.authorBulbiankova, Darya-
dc.contributor.authorDiaz-Puertas, Rocio-
dc.contributor.authorÁlvarez-Martínez, Francisco Javier-
dc.contributor.authorHerranz-Lopez, Maria-
dc.contributor.authorBarrajón-Catalán, Enrique-
dc.contributor.authorMicol, Vicente-
dc.contributor.otherDepartamentos de la UMH::Ingenieríaes_ES
dc.date.accessioned2024-01-09T09:53:43Z-
dc.date.available2024-01-09T09:53:43Z-
dc.date.created2023-02-
dc.identifier.citationAntioxidants 2023, 12(2)es_ES
dc.identifier.issn2076-3921-
dc.identifier.urihttps://hdl.handle.net/11000/30472-
dc.description.abstractAging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however, the chronic accumulation of senescent cells contributes to tissue dysfunction and aging. In this review, we discuss some of the most important hallmarks and biomarkers of cellular senescence with a special focus on skin biomarkers, reactive oxygen species (ROS), and senotherapeutic strategies to eliminate or prevent senescence. Although most of them are not exclusive to senescence, the expression of the senescence-associated beta-galactosidase (SA- -gal) enzyme seems to be the most reliable biomarker for distinguishing senescent cells from those arrested in the cell cycle. The presence of a stable DNA damage response (DDR) and the accumulation of senescence-associated secretory phenotype (SASP) mediators and ROS are the most representative hallmarks for senescence. Senotherapeutics based on natural compounds such as quercetin, naringenin, and apigenin have shown promising results regarding SASP reduction. These compounds seem to prevent the accumulation of senescent cells, most likely through the inhibition of pro-survival signaling pathways. Although studies are still required to verify their shortand long-term effects, these therapies may be an effective strategy for skin aginges_ES
dc.formatapplication/pdfes_ES
dc.format.extent26es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectaginges_ES
dc.subjectbiomarkeres_ES
dc.subjectROSes_ES
dc.subjectSASPes_ES
dc.subjectsenescencees_ES
dc.subjectsenotherapyes_ES
dc.subjectskines_ES
dc.subjectantioxidantes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnologíaes_ES
dc.titleHallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeuticses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/antiox12020444es_ES
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