Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/11000/30472

Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics


Vista previa

Ver/Abrir:
 antioxidants-12-00444-v2 (antiaging) reducido.pdf

896,24 kB
Adobe PDF
Compartir:
Título :
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Autor :
Bulbiankova, Darya
Diaz-Puertas, Rocio  
Álvarez-Martínez, Francisco Javier  
Herranz-Lopez, Maria  
Barrajón-Catalán, Enrique
Micol, Vicente  
Editor :
MDPI
Departamento:
Departamentos de la UMH::Ingeniería
Fecha de publicación:
2023-02
URI :
https://hdl.handle.net/11000/30472
Resumen :
Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however, the chronic accumulation of senescent cells contributes to tissue dysfunction and aging. In this review, we discuss some of the most important hallmarks and biomarkers of cellular senescence with a special focus on skin biomarkers, reactive oxygen species (ROS), and senotherapeutic strategies to eliminate or prevent senescence. Although most of them are not exclusive to senescence, the expression of the senescence-associated beta-galactosidase (SA- -gal) enzyme seems to be the most reliable biomarker for distinguishing senescent cells from those arrested in the cell cycle. The presence of a stable DNA damage response (DDR) and the accumulation of senescence-associated secretory phenotype (SASP) mediators and ROS are the most representative hallmarks for senescence. Senotherapeutics based on natural compounds such as quercetin, naringenin, and apigenin have shown promising results regarding SASP reduction. These compounds seem to prevent the accumulation of senescent cells, most likely through the inhibition of pro-survival signaling pathways. Although studies are still required to verify their shortand long-term effects, these therapies may be an effective strategy for skin aging
Palabras clave/Materias:
aging
biomarker
ROS
SASP
senescence
senotherapy
skin
antioxidant
Área de conocimiento :
CDU: Ciencias aplicadas: Ingeniería. Tecnología
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/openAccess
DOI :
https://doi.org/10.3390/antiox12020444
Aparece en las colecciones:
Artículos Ingeniería



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.