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https://hdl.handle.net/11000/39237Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sánchez-Hidalgo, Marina | - |
| dc.contributor.author | Fernández-Escamilla, Ana Mª | - |
| dc.contributor.author | Martínez-Bueno, Manuel | - |
| dc.contributor.author | Valdivia, Eva | - |
| dc.contributor.author | Serrano, Luis | - |
| dc.contributor.author | Maqueda, Mercedes | - |
| dc.contributor.other | Departamentos de la UMH::Bioquímica y Biología Molecular | es_ES |
| dc.date.accessioned | 2026-02-12T13:31:02Z | - |
| dc.date.available | 2026-02-12T13:31:02Z | - |
| dc.date.created | 2010-06 | - |
| dc.identifier.citation | Protein & Peptide Letters, Vol. 17, Nº 6 (2010) | es_ES |
| dc.identifier.issn | 1875-5305 | - |
| dc.identifier.issn | 0929-8665 | - |
| dc.identifier.uri | https://hdl.handle.net/11000/39237 | - |
| dc.description.abstract | Four AS-48 mutants (Trp24Ala, Gly13Lys, Leu40Lys and Ala53Ser) were obtained by site-directed mutagenesis. The minimal inhibitory concentration of each peptide showed that only residue Trp24 was unquestionably involved in the biological activity. Guanidine hydrochloride-induced unfolding assays showed a three-state transition denaturation process, suggesting a molten-globule-like conformation after the first transition. | es_ES |
| dc.format | application/pdf | es_ES |
| dc.format.extent | 7 | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Bentham Science Publishers | es_ES |
| dc.rights | info:eu-repo/semantics/closedAccess | es_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Circular antimicrobial peptides | es_ES |
| dc.subject | Site-directed mutagenesis | es_ES |
| dc.subject | Lactic-acid bacteria | es_ES |
| dc.subject | Enterococci | es_ES |
| dc.title | Conformational Stability and Activity of Circular Enterocin AS-48 Derivatives | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.relation.publisherversion | https://doi.org/10.2174/092986610791190390 | es_ES |
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