Título : Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial |
Autor : NAVARRO-LÓPEZ, Vicente MARTÍNEZ-ANDRÉS, Asunción Ramírez Boscá, Ana  Ruzafa-Costas, Beatriz  Núñez-Delegido, Eva  Carrión-Gutiérrez, Miguel  Prieto Merino, Antonio David  CODOÑER-CORTÉS, Francisco Ramón Vidal, Daniel  Genovés, Salvador  Chenoll, Empar  PÉREZ-ORQUÍN, José M. Pico-Monllor, JOSE ANTONIO  Chumillas, Sara  |
Editor : Medical Journals Sweden |
Departamento: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Fecha de publicación: 2019-08-27 |
URI : https://hdl.handle.net/11000/36541 |
Resumen :
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of at least 75% (p?0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
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Palabras clave/Materias: psoriasis dermatology probiotic microbiome microbiota |
Tipo de documento : info:eu-repo/semantics/article |
Derechos de acceso: info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
DOI : https://doi.org/10.2340/00015555-3305 |
Aparece en las colecciones: Artículos Farmacología, Pediatría y Química Orgánica
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