Título : Nasopharyngeal Microbiota as an early severity biomarker in COVID-19 hospitalised patients |
Autor : Ventero, Maria Paz  Moreno-Perez, Oscar  Molina-Pardines, Carmen Paytuví-Gallart, Andreu  Boix, Vicente  Escribano Cañadas , Isabel  Galán, Irene Gonzalez de la Aleja, Pilar  López-Pérez, Mario  Sánchez Martínez, Rosario  Merino de Lucas, Esperanza  RODRIGUEZ DIAZ, JUAN CARLOS  |
Editor : Elsevier |
Departamento: Departamentos de la UMH::Producción Vegetal y Microbiología |
Fecha de publicación: 2021-12-21 |
URI : https://hdl.handle.net/11000/35468 |
Resumen :
This study aimed to analyse the diversity and taxonomic composition of the nasopharyngeal microbiota, to determine its association with COVID-19 clinical outcome. To study the microbiota, we utilized 16S rRNA sequencing of 177 samples that came from a retrospective cohort of COVID-19 hospitalized patients. Raw sequences were processed by QIIME2. The associations between microbiota, invasive mechanical ventilation (IMV), and all-cause mortality were analysed by multiple logistic regression, adjusted for age, gender, and comorbidity. The microbiota α diversity indexes were lower in patients with a fatal outcome, whereas the β diversity analysis showed a significant clustering in these patients. After multivariate adjustment, the presence of Selenomonas spp., Filifactor spp., Actinobacillus spp., or Chroococcidiopsis spp., was associated with a reduction of more than 90% of IMV. Higher diversity and the presence of certain genera in the nasopharyngeal microbiota seem to be early biomarkers of a favourable clinical evolution in hospitalized COVID-19 patients
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Palabras clave/Materias: Biomarker COVID-19 Microbiota Prognosis SARS-COV-2 Severity |
Tipo de documento : info:eu-repo/semantics/article |
Derechos de acceso: info:eu-repo/semantics/closedAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
DOI : https://doi.org/10.1016/j.jinf.2021.12.030 |
Aparece en las colecciones: Artículos Producción vegetal y microbiología
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