Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/32361

OPRM1 Gene Interaction with Sleep in Chronic Pain Patients Treated with Opioids


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Title:
OPRM1 Gene Interaction with Sleep in Chronic Pain Patients Treated with Opioids
Authors:
Margarit, César
Ballester, Purificación
Inda, María del Mar
Roca, Reyes
Gomez, Luis  
Planelles, Beatriz
Ajo Ferrer, Raquel  
Morales, Domingo  
Peiró, Ana  
Editor:
Paducah, Ky. : American Society of Interventional Pain Physicians
Department:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Issue Date:
2019-01
URI:
https://hdl.handle.net/11000/32361
Abstract:
Background: The experience of chronic non-cancer pain (CNCP) is one of the most common reasons individuals seek medical attention. Patients with CNCP frequently experience concomitant sleep-related problems. Objectives: The aim was to evaluate sleep problems in opioid naïve CNCP patients, before and after opioid titration, analyzing the influence of OPRM1 gene variants. Study Design: A prospective, cohort, observational study. Setting: This study was performed at the Pain Unit of the Alicante University General Hospital. Methods: Pain and Medical Outcomes Study Sleep questionnaire (MOS-Sleep) were assessed at baseline and 3 months after opioid titration in 231 opioid naïve CNCP patients. Sleep data was compared with a matched-control group (n = 64). Morphine equivalent daily doses, adverse events, and drugs prescribed for pain were also registered. OPRM1 polymorphism rs1799971 was analyzed by RT-PCR. Ethics Committee approved the study and results were analyzed by R software. Results: After 3 months of opioid titration, patients with CNCP (63 ± 14 years, 64% female, VAS 74 ± 17 mm) significantly decreased pain intensity, anxiety and depression, and increased quality of life. Sleep problems were significantly more frequent in females (P = 0.002). Age, quality of life, anxiety, and depression all influenced sleep disturbances and problems indices, which were significantly different from the control group. Furthermore, the OPRM1 118- GG genotype was also associated with significantly lower sleep adequacy, and more sleep problems. Limitations: Total number of subjects studied was relatively small and most patients were on other non-opioid centrally-acting medications. Conclusions: Opioids decreased CNCP severity, improving patients’ psychological areas, and quality of life. However, patients with OPRM1 118-GG genotype indicated an increase in sleep problems and worsening sleep pattern while taking opioids.
Keywords/Subjects:
OPRM1
pharmacogenetics
MOS-Sleep
opioids
chronic noncancer pain
sleep related problems
sleep problem index SLP-6 and SLP-9
Knowledge area:
CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Appears in Collections:
Artículos Farmacología, Pediatría y Química Orgánica



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