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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Segura, Ana | - |
dc.contributor.author | Ballester, Purificación | - |
dc.contributor.author | Ajo Ferrer, Raquel | - |
dc.contributor.author | Inda, María del Mar | - |
dc.contributor.author | Urbano, Antonio | - |
dc.contributor.author | Muriel, Javier | - |
dc.contributor.author | Ochando, Isabel | - |
dc.contributor.author | Margarit, César | - |
dc.contributor.author | Martinez, Emi | - |
dc.contributor.author | Peiró, Ana | - |
dc.contributor.other | Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica | es_ES |
dc.date.accessioned | 2024-06-27T11:27:11Z | - |
dc.date.available | 2024-06-27T11:27:11Z | - |
dc.date.created | 2019 | - |
dc.identifier.citation | Gene. 2019:721S:100005 | es_ES |
dc.identifier.issn | 1879-0038 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | https://hdl.handle.net/11000/32360 | - |
dc.description.abstract | Objectives: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards. Subject patients/methods: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software. Results: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients. Conclusion: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards. | es_ES |
dc.format | application/pdf | es_ES |
dc.format.extent | 6 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chronic pain | es_ES |
dc.subject | Erectile dysfunction | es_ES |
dc.subject | Pharmacogenetics | es_ES |
dc.subject | T786C | es_ES |
dc.subject | eNOS gene | es_ES |
dc.subject | iPDE5 | es_ES |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología | es_ES |
dc.title | Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.gene.2019.100005 | es_ES |
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