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dc.contributor.authorSegura, Ana-
dc.contributor.authorBallester, Purificación-
dc.contributor.authorAjo Ferrer, Raquel-
dc.contributor.authorInda, María del Mar-
dc.contributor.authorUrbano, Antonio-
dc.contributor.authorMuriel, Javier-
dc.contributor.authorOchando, Isabel-
dc.contributor.authorMargarit, César-
dc.contributor.authorMartinez, Emi-
dc.contributor.authorPeiró, Ana-
dc.contributor.otherDepartamentos de la UMH::Farmacología, Pediatría y Química Orgánicaes_ES
dc.date.accessioned2024-06-27T11:27:11Z-
dc.date.available2024-06-27T11:27:11Z-
dc.date.created2019-
dc.identifier.citationGene. 2019:721S:100005es_ES
dc.identifier.issn1879-0038-
dc.identifier.issn0378-1119-
dc.identifier.urihttps://hdl.handle.net/11000/32360-
dc.description.abstractObjectives: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards. Subject patients/methods: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software. Results: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients. Conclusion: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChronic paines_ES
dc.subjectErectile dysfunctiones_ES
dc.subjectPharmacogeneticses_ES
dc.subjectT786Ces_ES
dc.subjecteNOS genees_ES
dc.subjectiPDE5es_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes_ES
dc.titleEndothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic paines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.gene.2019.100005es_ES
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Artículos Farmacología, Pediatría y Química Orgánica


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