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Sleep in autism: A biomolecular approach to aetiology and treatment


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Título :
Sleep in autism: A biomolecular approach to aetiology and treatment
Autor :
Ballester, Purificación
Richdale, A.L.
Baker, E.K.
Peiró, Ana  
Editor :
Elsevier
Departamento:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Fecha de publicación:
2020-07
URI :
https://hdl.handle.net/11000/32329
Resumen :
People with autism spectrum disorder (ASD) commonly experience other comorbidities. Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or disorders. The most commonly reported sleep problems are: (a) insomnia symptoms including the inability to get to sleep or stay asleep; and (b) circadian rhythm sleep-wake disorders, defined as a misalignment between the timing of endogenous circadian rhythms and the external environment. The circadian system provides timing information for the sleep-wake cycle that is regulated by the interaction of an endogenous processes (circadian - Process C, and homeostatic - Process S) and synchronizing agents (neurohormones and neurotransmitters), which produce somnogenic activity. A clinical priority in ASD is understanding the cause of these sleep problems in order to improve treatment outcomes. This review approaches sleep in autism from several perspectives: Sleep-wake mechanisms and problems, and brain areas and molecules controlling sleep (e.g., GABA and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). Specifically, this review examines how altered sleep structure could be related to neurobiological alterations or genetic mutations and the implications this may have for potential pharmacological treatments in individuals with ASD.
Palabras clave/Materias:
Autism spectrum disorder
Sleep problems
Insomnia
Circadian rhythm sleep-wake disorders
Pharmacological treatment
Neurotransmitters
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/closedAccess
DOI :
https://doi.org/10.1016/j.smrv.2020.101357
Aparece en las colecciones:
Artículos Farmacología, Pediatría y Química Orgánica



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