Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/11000/31402

Sex-Differences in Pain and Opioid Use Disorder Management: A Cross-Sectional Real-World Study

Título :
Sex-Differences in Pain and Opioid Use Disorder Management: A Cross-Sectional Real-World Study
Autor :
Escorial, Mónica  
Muriel, Javier  
César, Margarit
Laura, Agulló
Domingo, Morales
Peiró, Ana  
Editor :
MDPI
Departamento:
Departamentos de la UMH::Medicina Clínica
Fecha de publicación:
2022
URI :
https://hdl.handle.net/11000/31402
Resumen :
Background: It is essential to focus attention on sex-specific factors which are clinically relevant in pain management, especially with regards to opioid use disorder (OUD) risk. The aim of this study was to explore potential sex-differences in chronic non-cancer pain (CNCP) outpatients. (2) Methods: An observational cross-sectional study was conducted under CNCP outpatients with long-term prescribed opioids (n = 806), wherein 137 patients had an OUD diagnosis (cases, 64% females) and 669 did not (controls, 66% females). Socio-demographic, clinical, and pharmacological outcomes were analyzed. (3) Results: Female controls presented an older age and less intensive pain therapy but higher psychotropic prescriptions and emergency department visits compared to male controls. Meanwhile, cases demonstrated a younger age, higher work disability, double morphine equivalent daily dose, and benzodiazepine use compared with controls. Here, female cases showed an 8% greater substance use disorder (OR 2.04 [1.11-3.76]) and 24% lower tramadol use, while male cases presented a 22% higher fentanyl use (OR 2.97 [1.52-5.81]) and reported the highest number of adverse drug reactions (24%, OR 2.40 [1.12-5.16]) compared with controls. (4) Conclusions: An OUD individual risk profile was evidenced with sex-differences to take into consideration to design equal prevention programs.
Palabras clave/Materias:
opioid use disorder
sex-differences
chronic non-cancer pain;
gender disparities
pain management
prevention programs
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.3390/biomedicines10092302
Aparece en las colecciones:
Artículos Farmacología, Pediatría y Química Orgánica



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.