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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Badía Hernández, Pedro Valentín | - |
| dc.contributor.author | Mira Carrió, Amalia | - |
| dc.contributor.author | Losada Echeberria, María | - |
| dc.contributor.author | Díaz Puertas, Rocío | - |
| dc.contributor.author | Saceda Sánchez, Miguel | - |
| dc.contributor.author | García Morales, Pilar | - |
| dc.contributor.author | Mallavia Marín, Ricardo | - |
| dc.contributor.other | Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica | es_ES |
| dc.date.accessioned | 2026-07-31T08:40:05Z | - |
| dc.date.available | 2026-07-31T08:40:05Z | - |
| dc.date.created | 2025-06 | - |
| dc.identifier.uri | https://hdl.handle.net/11000/40309 | - |
| dc.description.abstract | INTRODUCTION Glioblastoma is an aggressive glioma with low incidence but high mortality, mainly due to its localization and the limited efficacy of current treatments (1). To overcome significant off-target toxicity due to systemic chemotherapy, localized delivery systems with controlled release, such as polymeric carmustine (BCNU) wafers under the name Gliadel®, are being explored (2). Encapsulating chemotherapeutics such as Doxorubicin (DOX) in polymeric nanofibers could offer a promising approach to enhance bioavailability and enable sustained, site-specific delivery. AIM In this work, poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) monoethyl ester (Es) and acid (Ac) nanofibers were synthesized as delivery systems for carmustine (BCNU) and doxorubicin (DOX). | es_ES |
| dc.format | application/pdf | es_ES |
| dc.format.extent | 1 | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Universidad Miguel Hernández | es_ES |
| dc.relation.ispartof | EACR Congress: Innovative Cancer Science 2025 | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | glioblastoma | es_ES |
| dc.subject | electrospun nanofibers | es_ES |
| dc.subject | PMVEMA | es_ES |
| dc.subject | drug delivery | es_ES |
| dc.subject | antineoplastic drugs | es_ES |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso | es_ES |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es_ES |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología | es_ES |
| dc.subject.other | CDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnología::620 - Ensayo de materiales. Materiales comerciales. Economía de la energía | es_ES |
| dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica | es_ES |
| dc.title | Development of post-surgical local delivery systems based on polymeric nanofibers for the administration of antineoplastic drugs against glioblastoma | es_ES |
| dc.type | info:eu-repo/semantics/other | es_ES |
| dc.contributor.institute | Institutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche | es_ES |

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13. Poster. EACR 2025. Development of post-surgical local delivery systems based on polymeric nanofibers for the administration of antineoplastic drugs against glioblastoma.pdf
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