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https://hdl.handle.net/11000/35238
ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention
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Title:
ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention |
Authors:
Cabañero, David 
Villalba Riquelme, Eva María
Fernández Ballester, Gregorio
Fernández Carvajal, Asia
Ferrer-Montiel, Antonio |
Editor:
Elsevier |
Department:
Departamentos de la UMH::Bioquímica y Biología Molecular |
Issue Date:
2022 |
URI:
https://hdl.handle.net/11000/35238 |
Abstract:
Chronicpainisamajorburdenforthesocietyandremainsmoreprevalentandsevereinfemales.Thepresenceofchronicpainislinkedtopersistentalterationsintheperipheralandthecentralnervoussystem. Oneof themaintypesofperipheralpaintransducersarethetransient receptorpotential channels (TRP),alsoknownasthermoTRPchannels,whichinterveneintheperceptionofhotandcoldexternal stimuli.Thesechannels,andespeciallyTRPV1,TRPA1andTRPM8,havebeensubjectedtoprofoundinvestigationbecauseoftheirroleasthermosensorsandalsobecauseoftheirimplicationinacuteandchronic pain.Surprisingly, theirsensitivitytoendogenoussignalinghasbeenfarlessstudied.Cumulativeevidencesuggeststhatthefunctionofthesechannelsmaybedifferentlymodulatedinmalesandfemales, inpartthroughsexualhormones,andthiscouldconstituteasignificantcontributortothesexdifferences inchronicpain.Here,wereviewtheexcitingadvancesinthermoTRPpharmacologyformalesandfemales intwoparadigmatictypesofchronicpainwithastrongperipheralcomponent:chronicmigraineand chemotherapy-inducedperipheralneuropathy(CIPN).Thepossibilitiesofperipheraldruggabilityoffered bythesechannelsandthedifferentialexploitationformenandwomenrepresentadevelopmentopportunitythatwill leadtoasignificantincrementofthearmamentariumofanalgesicmedicinesforpersonalizedchronicpaintreatment.
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Keywords/Subjects:
Nociceptors
Ionchannels
Inflammation
Neuropathic
Allodynia
Hyperalgesia
CGRP
Hormones
Menstrualcycle |
Knowledge area:
CDU: Ciencias puras y naturales: Biología |
Type of document:
info:eu-repo/semantics/article |
Access rights:
info:eu-repo/semantics/closedAccess |
DOI:
https://doi.org/10.1016/j.pharmthera.2022.108297 |
Appears in Collections:
Artículos Bioquímica y Biología Molecular
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