Título : Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoinmune diabetes through multiple immunosuppressive and anti-inflammatory responses |
Autor : Lachaud, C.C. Cobo-Vuilleumier, Nadia Fuente-Martin Diaz, I. Andreu, E. Cahuana, G.M. Tejedo, J.R. Hmadcha, Abdelkrim Gauthier, B.R. Soria |
Editor : Frontiers Media S.A |
Departamento: Departamentos de la UMH::Física Aplicada |
Fecha de publicación: 2023-02-15 |
URI : https://hdl.handle.net/11000/34719 |
Resumen :
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder specifically targeting pancreatic islet beta cells. Despite many efforts focused on identifying new therapies able to counteract this autoimmune attack and/or stimulate beta cells regeneration, TD1M remains without effective clinical treatments providing no clear advantages over the conventional treatment with insulin. We previously postulated that both the inflammatory and immune responses and beta cell survival/regeneration must be simultaneously targeted to blunt the
progression of disease. Umbilical cord-derived mesenchymal stromal cells (UC-MSC) exhibit anti-inflammatory, trophic, immunomodulatory and regenerative properties and have shown some beneficial yet controversial
effects in clinical trials for T1DM. In order to clarify conflicting results, we herein dissected the cellular and molecular events derived from UC-MSC intraperitoneal administration (i.p.) in the RIP-B7.1 mouse model of experimental autoimmune diabetes. Intraperitoneal (i.p.) transplantation of heterologous mouse UC-MSC delayed the onset of diabetes in RIP-B7.1 mice. Importantly, UC-MSC i. p. transplantation led to a strong peritoneal recruitment of myeloid-derived suppressor cells (MDSC) followed by multiple T-, B- and myeloid
cells immunosuppressive responses in peritoneal fluid cells, spleen, pancreatic lymph nodes and the pancreas, which displayed significantly reduced insulitis and pancreatic infiltration of T and B Cells and pro-inflammatory macrophages. Altogether, these results suggest that UC-MSC i. p. transplantation can block or delay the development of hyperglycemia through suppression of inflammation and the immune attack.
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Palabras clave/Materias: experimental autoimmune diabetes intraperitoneal transplantation inflammation immunomodulation insulitis Type I diabetes mellitus RIP-B7.1 UC-MSC |
Tipo de documento : info:eu-repo/semantics/article |
Derechos de acceso: info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
DOI : 10.3389/fcell.2023.1089817 |
Aparece en las colecciones: Artículos Física Aplicada
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