Title: Microbiota intestinal y probióticos: estrategias terapéuticas en dermatitis atópica |
Authors: Díaz Albero, Laura |
Tutor: Picó Monllor, José Antonio |
Editor: Universidad Miguel Hernández |
Department: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Issue Date: 2024-05-23 |
URI: https://hdl.handle.net/11000/32640 |
Abstract:
Introducción: La dermatitis atópica es uno de los problemas dermatológicos más comunes. A pesar de ello, el tratamiento convencional presenta una serie de inconvenientes como efectos adversos significativos y respuestas subóptimas. Tras la evidencia de la existencia de una correlación entre la piel... Ver más
Introduction: Atopic dermatitis is one of the most common dermatological problems. Despite this, conventional treatment presents a series of drawbacks such as significant adverse effects and suboptimal responses. Following the evidence of the existence of a correlation between the skin and the intestine, “gut-skin axis”, and the influence of this on the development and severity of inflammatory skin diseases such as AD, through imbalances in the intestinal microbiota, the hypothesis of the use of probiotics as a possible therapeutic strategy arises given its capacity to modulate the immune system through the regulation of microbial diversity, evaluating its effectiveness by reducing the severity of this pathology.
Objectives: To study the therapeutic efficacy of probiotic supplementation as an alternative treatment in reducing the symptoms and signs of atopic dermatitis.
Material and methods: A bibliographic review was carried out with the aim of gathering scientific evidence on the use of probiotics in atopic dermatitis for subsequent descriptive study and critical analysis. The data were obtained from direct consultation and access, via the Internet, to bibliographic databases in the field of health sciences: MEDLINE (via PubMed), Scopus, Embase and The Cochrane Library. The final search equation was carried out by using the descriptors "probiotics", "Dermatitis, Atopic" and “treatment outcome” after searching in the DeCS, the use of Boolean connectors and the application of the “clinical trial” filter.
Results: A total of 220 articles were recovered, of which, after applying the established inclusion and exclusion criteria, 17 were accepted for detailed review. The quality of the different studies was evaluated using the CONSORT observational studies guide, obtaining an average of 18 points out of a maximum of 25.
Conclusion: despite some disagreements and methodological limitations, the accumulated evidence mostly supports the use of probiotics as an effective therapeutic strategy in the treatment of AD. However, further studies with robust designs and transparent methodologies are needed to confirm these findings and better understand the underlying mechanisms
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Keywords/Subjects: Microbiota intestinal Dermatitis atópica Eczema Probióticos Simbióticos Suplementos alimenticios eficacia SCORAD |
Knowledge area: CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología |
Type of document: info:eu-repo/semantics/bachelorThesis |
Access rights: info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Appears in Collections: TFG - Farmacia
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