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Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level
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Título : Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level |
Autor : Barrajón-Catalán, Enrique Menéndez-Gutierrez, María P. Falcó, Alberto ![](/image/ORCID.jpg) Carrato, Alfredo Saceda, Miguel Micol, Vicente |
Editor : Elsevier |
Departamento: Departamentos de la UMH::Bioquímica y Biología Molecular |
Fecha de publicación: 2010-04-28 |
URI : https://hdl.handle.net/11000/31097 |
Resumen :
Trastuzumab (Herceptin™) targets the human epidermal growth factor receptor 2 (HER2), which is overexpressed in 20–30% of breast and ovarian cancers carrying a bad prognosis. Our purpose was to target HER2-overexpressing human breast cancer cells with pegylated immunoliposomes bearing trastuzumab and containing melittin, which has recently shown anticancer properties. Using a panel of human breast cancer cells with different HER2 expression levels, these immunoliposomes decreased cancer cells viability in a dose–response manner and in correlation to their level of HER2 expression. Specific binding of the immunoliposomes to SKBr3 breast cancer cells was shown by ImageStream-based analysis. The morphological changes observed in the treated cells suggested a cytolytic process. This preclinical approach may suppose an effective strategy for the treatment of HER2-overexpressing tumors, and can support the development of an early phases I–II clinical trial. Trastuzumab resistant breast cancer cells (JIMT-1), can also be targeted using this approach.
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Palabras clave/Materias: Trastuzumab Immunoliposomes MelittinCell Cell lysisHER2 HER2 Anticancer therapy Breast cancer cells |
Área de conocimiento : CDU: Ciencias puras y naturales: Biología |
Tipo documento : application/pdf |
Derechos de acceso: info:eu-repo/semantics/closedAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
DOI : https://doi.org/10.1016/j.canlet.2009.09.010 |
Aparece en las colecciones: Artículos Bioquímica y Biología Molecular
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La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.