Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30551

Switching from natalizumab to fingolimod: an observational study


Thumbnail

View/Open:
 1-Acta_switching (1) (1).pdf

128,62 kB
Adobe PDF
Share:
Title:
Switching from natalizumab to fingolimod: an observational study
Authors:
Perez-Sempere, Angel  
Martín-Medina, P.
Berenguer-Ruiz, L.
Pérez-Carmona, N.
Sanchez-Perez, R.
Polache-Vengud, J.
Feliu-Rey, E.
Editor:
Wiley
Department:
Departamentos de la UMH::Medicina Clínica
Issue Date:
2013-02
URI:
https://hdl.handle.net/11000/30551
Abstract:
Background – Multiple sclerosis patients who discontinue using natalizumab are at risk of a rebound in disease activity. However, the optimal alternative therapy is not currently known. Aims of the study – We report on clinical and MRI data and patient safety in a group of relapsing–remitting multiple sclerosis patients who tested seropositive for the JC virus and who have switched from natalizumab to fingolimod because of concerns regarding PML risks. Methods – The test for JC virus antibodies was performed in 18 relapsing–remitting multiple sclerosis patients who were being treated with natalizumab for more than 1 year. Eight seropositive patients switched to fingolimod while the seronegative patients continued with natalizumab. Results – After switching to fingolimod, five of eight patients (63%) experienced clinical relapses, and MRI activity was detected in six of eight patients (75%). Neither clinical relapses nor MRI activity was observed in the patients who continued with natalizumab. No serious adverse effects were detected. Conclusions – Natalizumab is an effective treatment for relapsing–remitting multiple sclerosis, but its discontinuation continues to be a complex problem. All of the therapies tried thus far, including fingolimod, have been unable to control the reactivation of the disease. Further studies addressing alternative therapies after natalizumab discontinuation are necessary.
Keywords/Subjects:
multiple sclerosis
treatment
MRI
natalizumab
fingolimod
Knowledge area:
CDU: Ciencias aplicadas: Medicina
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https://doi.org/10.1111/ane.12082
Appears in Collections:
Artículos Medicina Clínica



Creative Commons ???jsp.display-item.text9???