Please use this identifier to cite or link to this item:
https://hdl.handle.net/11000/30472
Hallmarks and Biomarkers of Skin Senescence: An Updated
Review of Skin Senotherapeutics
Title: Hallmarks and Biomarkers of Skin Senescence: An Updated
Review of Skin Senotherapeutics |
Authors: Bulbiankova, Darya Diaz-Puertas, Rocio ![](/image/ORCID.jpg) Álvarez-Martínez, Francisco Javier ![](/image/ORCID.jpg) Herranz-Lopez, Maria ![](/image/ORCID.jpg) Barrajón-Catalán, Enrique Micol, Vicente ![](/image/ORCID.jpg) |
Editor: MDPI |
Department: Departamentos de la UMH::Ingeniería |
Issue Date: 2023-02 |
URI: https://hdl.handle.net/11000/30472 |
Abstract:
Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular senescence has
been typically considered as an anti-proliferative process; however, the chronic accumulation of
senescent cells contributes to tissue dysfunction and aging. In this review, we discuss some of the most
important hallmarks and biomarkers of cellular senescence with a special focus on skin biomarkers,
reactive oxygen species (ROS), and senotherapeutic strategies to eliminate or prevent senescence.
Although most of them are not exclusive to senescence, the expression of the senescence-associated
beta-galactosidase (SA- -gal) enzyme seems to be the most reliable biomarker for distinguishing
senescent cells from those arrested in the cell cycle. The presence of a stable DNA damage response
(DDR) and the accumulation of senescence-associated secretory phenotype (SASP) mediators and ROS
are the most representative hallmarks for senescence. Senotherapeutics based on natural compounds
such as quercetin, naringenin, and apigenin have shown promising results regarding SASP reduction.
These compounds seem to prevent the accumulation of senescent cells, most likely through the
inhibition of pro-survival signaling pathways. Although studies are still required to verify their shortand
long-term effects, these therapies may be an effective strategy for skin aging
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Keywords/Subjects: aging biomarker ROS SASP senescence senotherapy skin antioxidant |
Knowledge area: CDU: Ciencias aplicadas: Ingeniería. Tecnología |
Type of document: application/pdf |
Access rights: info:eu-repo/semantics/openAccess |
DOI: https://doi.org/10.3390/antiox12020444 |
Appears in Collections: Artículos Ingeniería
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