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https://hdl.handle.net/11000/30424
Aggregation of 25-hydroxycholesterol in a complex biomembrane.
Differences with cholesterol
Título : Aggregation of 25-hydroxycholesterol in a complex biomembrane.
Differences with cholesterol |
Autor : Galiano, Vicente Villalaín, José |
Editor : Elsevier |
Departamento: Departamentos de la UMH::Ingeniería de Computadores |
Fecha de publicación: 2020-07 |
URI : https://hdl.handle.net/11000/30424 |
Resumen :
25-Hydroxycholesterol (25HC), one of the most important oxysterol molecules, can be used by cells to fight
bacterial and viral infections but the mechanism that defines its biological effects are unknown. Using molecular
dynamics, we have aimed to describe the orientation and location of 25HC in the membrane as well as the
interactions it might have with lipids. We have studied two complex model membrane systems, one similar to
the late endosome membrane and the other one to the plasma membrane. Our results reinforce that 25HC is
inserted in the membrane in a relative stable location similar to but not identical to cholesterol. 25HC fluctuates
in the membrane to a much greater degree than cholesterol, but the effect of 25HC on the phospholipid order
parameters is not significantly different. One of the most notable facts about 25HC is that, unlike cholesterol, this
molecule tends to aggregate, forming dimers, trimers and higher-order aggregates. These aggregates are formed
spontaneously through the formation of hydrogen bonds between the two 25HC atoms, the formation of hydrogen bonds being independent of the studied system. Remarkably, no contacts or hydrogen bonds are observed
between 25HC and cholesterol molecules, as well as between cholesterol molecules themselves at any time. It
would be conceivable that 25HC, by forming high order aggregates without significantly altering the membrane
properties, would modify the way proteins interact with the membrane and henceforth form a true innate antiviral molecule.
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Palabras clave/Materias: 25-Hydroxycholesterol Late endosome membrane Plasma membrane Bis(monoacylglycero)phosphate Cholesterol |
Área de conocimiento : CDU: Ciencias aplicadas: Ingeniería. Tecnología |
Tipo documento : application/pdf |
Derechos de acceso: info:eu-repo/semantics/openAccess |
DOI : https://doi.org/10.1016/j.bbamem.2020.183413 |
Aparece en las colecciones: Artículos Ingeniería de computadores
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La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.