Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31294
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dc.contributor.authorPetermann Rocha, Fanny-
dc.contributor.authorValera Gran, Desiree-
dc.contributor.authorFernández Pires, Paula-
dc.contributor.authorMartens, Dries S.-
dc.contributor.authorJúlvez, Jordi-
dc.contributor.authorRodríguez Dehli, Cristina-
dc.contributor.authorAndianera, Ainara-
dc.contributor.authorLozano, Manuel-
dc.contributor.authorFernández Somoano, Ana-
dc.contributor.authorLertxundi, Aitana-
dc.contributor.authorLlop, Sabrina-
dc.contributor.authorGuxens, Mónica-
dc.contributor.authorNawrot, Tim S.-
dc.contributor.authorNavarrete Muñoz, Eva María-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.date.accessioned2024-02-08T11:51:45Z-
dc.date.available2024-02-08T11:51:45Z-
dc.date.created2023-04-
dc.identifier.citationPediatric Research 2023 Apr;93(5):1419-1424es_ES
dc.identifier.issn0031-3998-
dc.identifier.issn1530-0447-
dc.identifier.urihttps://hdl.handle.net/11000/31294-
dc.description.abstractBackground: Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data. Methods: A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day). Leucocyte TL at 4 and 7-9 years were measured using quantitative PCR methods. Multiple robust linear regression models, through log-level regression models, were used to report the % of difference among tertiles of sleep duration. Results: In comparison to children who slept between >10 and 11 h/day, those in the highest category (more than 11 h/day) had 8.5% (95% CI: 3.56-13.6) longer telomeres at 4 years. Longitudinal analysis showed no significant association between sleep duration at 4 years and TL at 7-9 years. Conclusion: Children who slept more hours per day had longer TL at 4 years independently of a wide range of confounder factors. Environmental conditions, such as sleep duration, might have a major impact on TL during the first years of life. Impact: Telomere length was longer in children with longer sleep duration (>11 h/day) independently of a wide range of confounder factors at age 4 and remained consistent by sex. Sleep routines are encouraged to promote positive child development, like the number of hours of sleep duration. Considering the complex biology of telomere length, future studies still need to elucidate which biological pathways might explain the association between sleep duration and telomere lengthes_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isospaes_ES
dc.publisherSpringer Nature [academic journals on nature.com] [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleChildren who sleep more may have longer telomeres: evidence from a longitudinal population study in Spaines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps//:10.1038/s41390-022-02255-wes_ES
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Artículos Patología y Cirugía


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