Please use this identifier to cite or link to this item: http://dspace.umh.es/handle/11000/4230

Clock genes, pancreatic function and diabetes

Title:
Clock genes, pancreatic function and diabetes
Authors:
Vieira, Elaine
Burris, Thomas P.
Quesada, Ivan
Department:
Biología Aplicada
Issue Date:
2017-11-03
Abstract:
Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic β cells, glucose homeostasis, and diabetes.
Keywords/Subjects:
clock genes
diabetes
pancreas
β cell
insulin
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Appears in Collections:
Artículos



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