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dc.contributor.authorVieira, Elaine-
dc.contributor.authorBurris, Thomas P.-
dc.contributor.authorQuesada, Ivan-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes
dc.date.accessioned2017-11-03T15:52:01Z-
dc.date.available2017-11-03T15:52:01Z-
dc.date.created2014-11-05-
dc.date.issued2017-11-03-
dc.identifier.urihttp://hdl.handle.net/11000/4230-
dc.description.abstractCircadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic β cells, glucose homeostasis, and diabetes.es
dc.description.sponsorshipThis work was supported by grants from the Ministerio de Economía (BFU2013-42789)-
dc.description.sponsorshipThis work was supported by grants from Generalitat Valenciana (PROMETEO/2011/080)-
dc.formatapplication/pdfes
dc.format.extent31es
dc.language.isoenges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectclock geneses
dc.subjectdiabeteses
dc.subjectpancreases
dc.subjectβ celles
dc.subjectinsulines
dc.subject.otherBiologíaes
dc.titleClock genes, pancreatic function and diabeteses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.molmed.2014.10.007-
dc.relation.publisherversionhttps://doi.org/10.1016/j.molmed.2014.10.007-
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