Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31294

Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain


no-thumbnailView/Open:

 Children who sleep more may have longer telomeres evidence.pdf



581,7 kB
Adobe PDF
Share:

This resource is restricted

Title:
Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain
Authors:
Petermann Rocha, Fanny
Valera Gran, Desiree
Fernández Pires, Paula
Martens, Dries S.
Júlvez, Jordi
Rodríguez Dehli, Cristina
Andianera, Ainara
Lozano, Manuel
Fernández Somoano, Ana
Lertxundi, Aitana
Llop, Sabrina
Guxens, Mónica
Nawrot, Tim S.
Navarrete Muñoz, Eva María
Editor:
Springer Nature [academic journals on nature.com] [Commercial Publisher]
Department:
Departamentos de la UMH::Patología y Cirugía
Issue Date:
2023-04
URI:
https://hdl.handle.net/11000/31294
Abstract:
Background: Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data. Methods: A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day). Leucocyte TL at 4 and 7-9 years were measured using quantitative PCR methods. Multiple robust linear regression models, through log-level regression models, were used to report the % of difference among tertiles of sleep duration. Results: In comparison to children who slept between >10 and 11 h/day, those in the highest category (more than 11 h/day) had 8.5% (95% CI: 3.56-13.6) longer telomeres at 4 years. Longitudinal analysis showed no significant association between sleep duration at 4 years and TL at 7-9 years. Conclusion: Children who slept more hours per day had longer TL at 4 years independently of a wide range of confounder factors. Environmental conditions, such as sleep duration, might have a major impact on TL during the first years of life. Impact: Telomere length was longer in children with longer sleep duration (>11 h/day) independently of a wide range of confounder factors at age 4 and remained consistent by sex. Sleep routines are encouraged to promote positive child development, like the number of hours of sleep duration. Considering the complex biology of telomere length, future studies still need to elucidate which biological pathways might explain the association between sleep duration and telomere length
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https//:10.1038/s41390-022-02255-w
Appears in Collections:
Artículos Patología y Cirugía



Creative Commons ???jsp.display-item.text9???