Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31171

Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus

Title:
Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus
Authors:
Company Devesa, Verónica
Murcia Ramón, Raquel
Andreu Cervera, Abraham
Aracil Pastor, Paula
Almagro García, Francisca de Paula
Martínez Pérez, Salvador
Echevarría Aza, Diego
de Puelles Martínez de La Torre, Eduardo
Editor:
Wiley [Commercial Publisher]
Department:
Departamentos de la UMH::Patología y Cirugía
Instituto de Neurociencias
Departamentos de la UMH::Histología y Anatomía
Issue Date:
2022-11
URI:
https://hdl.handle.net/11000/31171
Abstract:
Background: The fasciculus retroflexus is the prominent efferent pathway from the habenular complex. Medial habenular axons form a core packet whereas lateral habenular axons course in a surrounding shell. Both groups of fibers share the same initial pathway but differ in the final segment of the tract, supposedly regulated by surface molecules. The gene Amigo2 codes for a membrane adhesion molecule with an immunoglobulin-like domain 2 and is selectively expressed in the medial habenula. We present it as a candidate for controlling the fasciculation behavior of medial habenula axons. Results: First, we studied the development of the habenular efferents in an Amigo2 lack of function mouse model. The fasciculus retroflexus showed a variable defasciculation phenotype. Gain of function experiments allowed us to generate a more condensed tract and rescued the Amigo2 knock-out phenotype. Changes in Amigo2 function did not alter the course of habenular fibers. Conclusion: We have demonstrated that Amigo2 plays a subtle role in the fasciculation of the fasciculus retroflexus
Keywords/Subjects:
Amigo2
fasciculation
fasciculus retroflexus
lateral habenula
medial habenula
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.1002/dvdy.513
Appears in Collections:
Artículos Patología y Cirugía



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