Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31169

Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus

Title:
Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus
Authors:
Company Devesa, Verónica
Moreno Cerdá, Ana
Andreu Cervera, Abraham
Murcia Ramón, Raquel
Almagro García, Francisca de Paula
Echevarría Aza, Diego
Martínez Pérez, Salvador
de Puelles Martínez de La Torre, Eduardo
Editor:
Frontiers Media [Commercial Publisher]
Department:
Departamentos de la UMH::Patología y Cirugía
Instituto de Neurociencias
Departamentos de la UMH::Histología y Anatomía
Issue Date:
2021-10
URI:
https://hdl.handle.net/11000/31169
Abstract:
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is involved in the limbic system and its malfunction is related with several psychiatric disorders. Our aim is to elucidate the Wnt1 role in the habenula and its main efferent tract, the fasciculus retroflexus, development. In order to achieve these objectives, we analyzed these structures development in a Wnt1 lack of function mouse model. The habenula was generated in our model, but it presented an enlarged volume. This alteration was due to an increment in habenular neuroblasts proliferation rate. The fasciculus retroflexus also presented a wider and disorganized distribution and a disturbed final trajectory toward its target. The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the habenula is Wnt1 independent. Nevertheless, it controls its precursors proliferation rate. Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. The alteration of these areas is responsible for the fasciculus retroflexus axons misroute
Keywords/Subjects:
Wnt1
differentiation
fasciculus retroflexus
habenula
proliferation.
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.3389/fcell.2021.755729
Appears in Collections:
Artículos Patología y Cirugía



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