Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31168
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dc.contributor.authorCompany Devesa, Verónica-
dc.contributor.authorAndreu Cervera, Abraham-
dc.contributor.authorMadrigal Verdú, María del Pilar-
dc.contributor.authorAndrés Bayón, Belén-
dc.contributor.authorAlmagro García, Francisca de Paula-
dc.contributor.authorChedotal, Alain-
dc.contributor.authorLópez Bendito, Guillermina-
dc.contributor.authorMartínez Pérez, Salvador-
dc.contributor.authorEchevarría Aza, Diego-
dc.contributor.authorMoreno Bravo, Juan Antonio-
dc.contributor.authorde Puelles Martínez de La Torre, Eduardo-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.contributor.otherDepartamentos de la UMH::Histología y Anatomíaes_ES
dc.contributor.otherInstituto de Neurocienciases_ES
dc.date.accessioned2024-02-06T17:13:59Z-
dc.date.available2024-02-06T17:13:59Z-
dc.date.created2021-06-
dc.identifier.citationFrontiers in cell and developmental biology 2021 Jun 8:9:682067es_ES
dc.identifier.issnElectronic: 2296-634X-
dc.identifier.urihttps://hdl.handle.net/11000/31168-
dc.description.abstractThe fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organization of habenular circuitry requires complex molecular programs to control the wiring of the habenula during development. However, the mechanisms guiding the habenular axons toward their targets remain mostly unknown. Here, we demonstrate the role of the mesodiencephalic dopaminergic neurons (substantia nigra pars compacta and ventral tegmental area) as an intermediate target for the correct medial habenular axons navigation along the anteroposterior axis. These neuronal populations are distributed along the anteroposterior trajectory of these axons in the mesodiencephalic basal plate. Using in vitro and in vivo experiments, we determined that this navigation is the result of netrin 1 attraction generated by the mesodiencephalic dopaminergic neurons. This attraction is mediated by the receptor deleted in colorectal cancer (DCC), which is strongly expressed in the medial habenular axons. The increment in our knowledge on the fasciculus retroflexus trajectory guidance mechanisms opens the possibility of analyzing if its alteration in mental health patients could account for some of their symptomses_ES
dc.formatapplication/pdfes_ES
dc.format.extent16es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDCCes_ES
dc.subjectaxon guidancees_ES
dc.subjectfasciculus retroflexuses_ES
dc.subjecthabenulaes_ES
dc.subjectnetrin 1es_ES
dc.subjectsubstantia nigra pars compactaes_ES
dc.subjectventral tegmental areaes_ES
dc.titleNetrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axonses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2021.682067es_ES
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Artículos Patología y Cirugía


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