Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31167
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMurcia Ramón, Raquel-
dc.contributor.authorCompany Devesa, Verónica-
dc.contributor.authorJuárez Leal, Iris-
dc.contributor.authorAndreu Cervera, Abraham-
dc.contributor.authorAlmagro García, Francisca de Paula-
dc.contributor.authorMartínez Pérez, Salvador-
dc.contributor.authorEchevarría Aza, Diego-
dc.contributor.authorde Puelles Martínez de La Torre, Eduardo-
dc.contributor.otherInstituto de Neurocienciaes_ES
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.contributor.otherDepartamentos de la UMH::Histología y Anatomíaes_ES
dc.date.accessioned2024-02-06T17:12:17Z-
dc.date.available2024-02-06T17:12:17Z-
dc.date.created2020-12-
dc.identifier.citationBrain structure & function 2020 Dec;225(9):2857-2869es_ES
dc.identifier.issn1863-2653-
dc.identifier.issn1863-2661-
dc.identifier.urihttps://hdl.handle.net/11000/31167-
dc.description.abstractDuring the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalamic region. With this purpose, we used a transgenic mouse line that expresses the tdTomato reporter driven by the promotor of Nkx2.1. Analysing the Nkx2.1-positive derivatives at E18.5, we found neural contributions to the prethalamic region, mainly in the zona incerta and in the mes-diencephalic tegmental region. We studied the developing hypothalamus along the embryonic period. From E10.5 we detected that the Nkx2.1 expression domain was narrower than the reporter distribution. Therefore, the Nkx2.1 expression fades in a great number of the early-born neurons from the Nkx2.1-positive territory. At the most caudal positive part, we detected a thin stream of positive neurons migrating caudally into the mes-diencephalic tegmental region using time-lapse experiments on open neural tube explants. Late in development, we found a second migratory stream into the prethalamic territory. All these tangentially migrated neurons developed a gabaergic phenotype. In summary, we have described the contribution of interneurons from the Nkx2.1-positive hypothalamic territory into two different rostrocaudal territories: the mes-diencephalic reticular formation through a caudal tangential migration and the prethalamic zona incerta complex through a dorsocaudal tangential migrationes_ES
dc.formatapplication/pdfes_ES
dc.format.extent13es_ES
dc.language.isoenges_ES
dc.publisherSpringer [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypothalamuses_ES
dc.subjectNkx2.1es_ES
dc.subjectReticular formationes_ES
dc.subjectTangential migrationes_ES
dc.subjectZona incertaes_ES
dc.titleNeuronal tangential migration from Nkx2.1-positive hypothalamuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps//:10.1007/s00429-020-02163-xes_ES
Appears in Collections:
Artículos Patología y Cirugía


Thumbnail

View/Open:
 Neuronal tangential migration from Nkx2.1‑positive hypothalamus.pdf

2,79 MB
Adobe PDF
Share:


Creative Commons ???jsp.display-item.text9???