Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31167

Neuronal tangential migration from Nkx2.1-positive hypothalamus

Title:
Neuronal tangential migration from Nkx2.1-positive hypothalamus
Authors:
Murcia Ramón, Raquel
Company Devesa, Verónica
Juárez Leal, Iris
Andreu Cervera, Abraham
Almagro García, Francisca de Paula
Martínez Pérez, Salvador
Echevarría Aza, Diego
de Puelles Martínez de La Torre, Eduardo
Editor:
Springer [Commercial Publisher]
Department:
Instituto de Neurociencia
Departamentos de la UMH::Patología y Cirugía
Departamentos de la UMH::Histología y Anatomía
Issue Date:
2020-12
URI:
https://hdl.handle.net/11000/31167
Abstract:
During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalamic region. With this purpose, we used a transgenic mouse line that expresses the tdTomato reporter driven by the promotor of Nkx2.1. Analysing the Nkx2.1-positive derivatives at E18.5, we found neural contributions to the prethalamic region, mainly in the zona incerta and in the mes-diencephalic tegmental region. We studied the developing hypothalamus along the embryonic period. From E10.5 we detected that the Nkx2.1 expression domain was narrower than the reporter distribution. Therefore, the Nkx2.1 expression fades in a great number of the early-born neurons from the Nkx2.1-positive territory. At the most caudal positive part, we detected a thin stream of positive neurons migrating caudally into the mes-diencephalic tegmental region using time-lapse experiments on open neural tube explants. Late in development, we found a second migratory stream into the prethalamic territory. All these tangentially migrated neurons developed a gabaergic phenotype. In summary, we have described the contribution of interneurons from the Nkx2.1-positive hypothalamic territory into two different rostrocaudal territories: the mes-diencephalic reticular formation through a caudal tangential migration and the prethalamic zona incerta complex through a dorsocaudal tangential migration
Keywords/Subjects:
Hypothalamus
Nkx2.1
Reticular formation
Tangential migration
Zona incerta
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https//:10.1007/s00429-020-02163-x
Appears in Collections:
Artículos Patología y Cirugía



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