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Risk factors for major adverse cardiovascular events in postmenopausal women: UK Biobank prospective cohort study


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Title:
Risk factors for major adverse cardiovascular events in postmenopausal women: UK Biobank prospective cohort study
Authors:
Bertomeu-González, Vicente  
Cordero, Alberto  
Ruiz-Nodar, Juan Miguel
Sánchez-Ferrer, Francisco
López-Pineda, Adriana
Quesada, José Antonio
Editor:
Elsevier
Department:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Issue Date:
2023
URI:
https://hdl.handle.net/11000/30862
Abstract:
Background and aims Cardiovascular risk increases during menopause, so the medical and scientific community should consider women's specific risk factors to prevent cardiovascular disease. This study aims to assess the risk factors for the incidence of major adverse cardiovascular events (MACE) exclusive to postmenopausal women. Methods We conducted a prospective cohort study in postmenopausal women aged 40 years and older, who were included in the UK Biobank cohort between 2006 and 2010 and followed to 2021 (12 years). A total of 156,787 women were followed for a median of 12.5 years (nearly 2 million person-years), and MACE risk was assessed using Fine-Gray competing risk models. Results The cumulative incidence of cardiovascular morbidity and mortality was 1.2% (0.97 cases per 1000 women-years). Not having taken birth control pills, not having children, and early menarche (≤12 years) were independently associated with cardiovascular morbidity and mortality. Conclusions Risk factors for cardiovascular disease that are specific to women include early menarche, not having taken oral contraceptives, and reproductive history, and this relationship is independent of classic cardiovascular risk factors.
Keywords/Subjects:
Menopause
Cardiovascular disease
Morbidity
Mortality
Female risk factors
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https://doi.org/10.1016/j.atherosclerosis.2023.117372
Appears in Collections:
Artículos Farmacología, Pediatría y Química Orgánica



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