Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30789

Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain

Title:
Inorganic arsenic exposure and neuropsychological development of children of 4–5 years of age living in Spain
Authors:
Signes-Pastor, Antonio Jose  
Vioque, Jesús
Navarrete-Muñoz, Eva María
Carey, Manus  
García Villarino, Miguel  
Fernández Somoano, Ana
Tardón, Anodina
SANTA MARINA, LORETO  
Irizar, Amaia  
Casas, Maribel  
Guxens, Mònica  
Llop, Sabrina
Soler-Blasco, Raquel  
Garcia de la Hera, Manuela  
Karagas, Margaret R  
Meharg, Andrew A.
Editor:
Elsevier
Department:
Departamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecología
Issue Date:
2019
URI:
https://hdl.handle.net/11000/30789
Abstract:
Early-life exposure to inorganic arsenic (iAs) may adversely impact health later in life. To date, evidence of iAs adverse effects on children's neurodevelopment comes mainly from populations highly exposed to contaminated water with conflicting results. Little is known about those effects among populations with low iAs exposure from food intake. We investigated the cross-sectional association between exposure to iAs and neurodevelopment scores among children living in Spain whose main route of exposure was diet. Arsenic species concentrations in urine from 400 children was determined, and the sum of urinary iAs, dimethylarsinic acid, and monomethylarsonic acid was used to estimate iAs exposure. The McCarthy Scales of Children's Abilities was used to assess children's neuropsychological development at about 4–5 years of age. The median (interquartile range) of children's sum of urinary iAs, MMA, and DMA was 4.85 (2.74–7.54) μg/L, and in adjusted linear regression analyses the natural logarithm transformed concentrations showed an inverse association with children's motor functions (β, [95% confidence interval]; global scores (−2.29, [-3.95, −0.63])), gross scores (−1.92, [-3.52, −0.31]) and fine scores (−1.54, [-3.06, −0.03]). In stratified analyses by sex, negative associations were observed with the scores in the quantitative index (−2.59, [-5.36, 0.17]) and working memory function (−2.56, [-5.36, 0.24]) only in boys. Our study suggests that relatively low iAs exposure may impair children's neuropsychological development and that sex-related differences may be present in susceptibility to iAs related effects; however, our findings should be interpreted with caution given the possibility of residual confounding.
Keywords/Subjects:
Urinary arsenic species
Inorganic arsenic
Children
Neuropsychological development
Dietary arsenic
Developmental toxicology
Neurodevelopment
Environment
McCarthy scales of Children's abilities
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https://doi.org/10.1016/j.envres.2019.04.028
Appears in Collections:
Artículos Salud Pública, Historia de la Ciencia y Ginecología



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