Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/29196

Comparative evaluation of two collagenbased biomaterials with different compositions used for bone graft: An experimental animal study


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Title:
Comparative evaluation of two collagenbased biomaterials with different compositions used for bone graft: An experimental animal study
Authors:
Gehrke, Sergio  
Aramburú Junior, Jaime  
Eliers Treichel, Tiago Luis
Rodriguez, Fernando  
De Aza, Piedad  
Dedavid, Berenice Anina  
Department:
Departamentos de la UMH::Ciencia de Materiales, Óptica y Tecnología Electrónica
Issue Date:
2022-07
URI:
https://hdl.handle.net/11000/29196
Abstract:
A large number of materials with different compositions and shapes have been proposed and studied for the purpose of bone tissue regeneration. Collagen-based materials have shown promising results for this application, with improved physicochemical properties. The aim of the present in vivo animal study was to evaluate and compare two commercially available collagen-based biomaterials for bone regeneration, with these being implanted in circumferential bone defects created in the calvarium of rabbits. Twenty rabbits received bilateral parietal osteotomies, performed with the aid of a 6.5 mm diameter trephine. Two groups were created: the BC group, where the defect was filled with a scaffold composed of 90% bovine bone particles and 10% porcine collagen, and the EG group, where the defect was filled with a scaffold composed of 75% hydroxyapatite particles of bovine origin and 25% bovine collagen. Ten animals were sacrificed at 30 days and another 10 at 45 days after implantation, and the samples were processed and histologically analyzed. In the evaluations of the samples at 30 days, no important differences were found in the results. However, in the samples at 45 days after surgery, the EG group showed better results than the BC group samples, mainly in terms of the amount of bone matrix formation (P < 0.0001) and the volume in area measured in each sample, where the EG group had a value 65% higher than that in the BC group samples. Based on the results obtained, we conclude that the amount of collagen and the particle characteristics present in the composition of the scaffolds can directly influence the amount of neoformation and/or bone regeneration.
Keywords/Subjects:
Animal study
bone defect
bone ingrowth
bone regeneration
collagen-based biomaterials
Knowledge area:
CDU: Ciencias aplicadas: Ingeniería. Tecnología
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.1177/22808000221119650
Appears in Collections:
Artículos CIENCIA DE LOS MATERIALES ÓPTICA Y TECNOLOGÍA ELECTRÓNICA



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