Determining Monkey Free Choice Long before the Choice Is Made: The Principal Role of Prefrontal Neurons Involved in Both Decision and Motor Processes

Abstract

When choices are made freely, they might emerge from pre-existing neural activity. However, whether neurons in the prefrontal cortex (PF) show this anticipatory effect and, if so, in which part of the process they are involved is still debated. To answer this question, we studied PF activity in monkeys while they performed a strategy task. In this task when the stimulus changed from the previous trial, the monkeys had to shift their response to one of two spatial goals, excluding the one that had been previously selected. Under this free-choice condition, the prestimulus activity of the same neurons that are involved in decision and motor processes predicted future choices. These neurons developed the same goal preferences during the prestimulus presentation as they did later in the decision phase. In contrast, the same effect was not observed in motor-only neurons and it was present but weaker in decision-only neurons. Overall, our results suggest that the PF neuronal activity predicts upcoming actions mainly through the decision-making network that integrate in time decision and motor task aspects.