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https://hdl.handle.net/11000/33714
Metodología de la determinación de la grasa fecal y del coeficiente de absorción de grasas en ensayos clínicos aleatorizados. Una revisión sistemática
Título : Metodología de la determinación de la grasa fecal y del coeficiente de absorción de grasas en ensayos clínicos aleatorizados. Una revisión sistemática |
Autor : Carrillo Tormo, Isabel |
Tutor: de Madaria Pascual, Enrique Garay Montiel, María Belén |
Editor : Universidad Miguel Hernández |
Departamento: Departamentos de la UMH::Medicina Clínica |
Fecha de publicación: 2024-04-28 |
URI : https://hdl.handle.net/11000/33714 |
Resumen :
Objetivo
El objetivo principal de este estudio es identificar y revisar la literatura para analizar la
homogeneidad y describir la metodología en la que la determinación de la grasa fecal y
el cálculo del coeficiente de absorción de grasas (CAG) son realizados en diferentes
ensayos clínicos aleator... Ver más
Objective
The main objective of this study is to identify and review the literature to analyze the
homogeneity and describe the methodology in which the determination of fecal fat and
the calculation of coefficient of fat absorption (CFA) are performed in various
randomized clinical trials of PEI.
Methods
A bibliographic search was conducted in PubMed and Cochrane Central with a cutoff
date of 13-11-2023. The specific terms used for the search in all databases were:
(randomize OR randomized) AND "Exocrine Pancreatic Insufficiency" [MESH]. Two
independent reviewers completed the search and study selection process, as well as
data extraction (MBG and ICT); disagreements were resolved by a third reviewer (EDM). All controlled randomized clinical trials (RCTs) in which fecal fat or coefficient of fat
absorption (CFA) were considered as gold standards and the study population was
predisposed to PEI (PP-PEI) were selected. Data regarding study design, description of
the study population, and methodology for quantifying fecal fat were recorded, and the
obtained data were analyzed.
Results
The determination of fecal fat for the calculation of CFA is a test that is not performed
homogeneously nor follows a standardized protocol across studies. The methodology of
this test, considered as the gold standard for the diagnosis of PEI, exhibits considerable
variability among the different reviewed studies, suggesting in turn a high variability in
the results obtained depending on the procedure employed.
Conclusions
The lack of homogeneity in the procedure of fecal fat determination, along with other
limitations of this test, make the CFA not an appropriate gold standard for the diagnosis
of PEI, justifying the need for new studies to search for alternatives to the current gold
standard.
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Palabras clave/Materias: Insuficiencia pancreática exocrina determinación de la grasa fecal coeficiente de absorción de grasas patología pancreática malabsorción de grasas esteatorrea test de Van de Kamer |
Área de conocimiento : CDU: Ciencias aplicadas: Medicina |
Tipo de documento : info:eu-repo/semantics/bachelorThesis |
Derechos de acceso: info:eu-repo/semantics/openAccess |
Aparece en las colecciones: TFG- Medicina
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La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.