Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31211
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dc.contributor.authorMata-Balaguer, Trinidad-
dc.contributor.authorCuchillo-Ibañez, Inmaculada-
dc.contributor.authorCalero, Miguel-
dc.contributor.authorFerrer, Isidro-
dc.contributor.authorSáez-Valero, Javier-
dc.date.accessioned2024-02-07T10:24:48Z-
dc.date.available2024-02-07T10:24:48Z-
dc.date.created2018-02-09-
dc.identifier.citationThe FASEB Journal Volume 32, Issue 7Jul 2018 3485-4064es_ES
dc.identifier.issn1530-6860-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://hdl.handle.net/11000/31211-
dc.description.abstractIncreasing evidence indicates that altered reelin signaling could contribute to synaptic dysfunction in Alzheimer's disease (AD). We found that reelin protein and mRNA levels were increased in the AD brain (particularly at advanced Braak stages in apolipoprotein E4 noncarriers), compared with that of control subjects. The β-amyloid (Aβ) protein impairs reelin activity and increases reelin expression through a mechanism that is not yet understood. To explore that mechanism, we examined the effect of Aβ aa 1-42 (Aβ42) on DNA methylation of the RELN promoter and the processing of reelin receptor apolipoprotein E receptor 2 (ApoER2) in differentiated SH-SY5Y cells because ApoER2 C-terminal fragments (CTFs), generated after reelin binding, regulate reelin expression. We found that Aβ42 decreased nuclear levels of DNA-methyltransferase 1. However, RELN promoter methylation did not change in Aβ42-treated cells or in AD brain extracts. Instead, the levels of ApoER2-CTF appeared significantly lower in Aβ42-treated cells and in AD extracts from advanced Braak stages of apolipoprotein E4 noncarriers. Our data show that ApoER2-CTF levels are decreased, whereas reelin expression is increased in AD brain at advanced Braak stages and after Aβ treatment, supporting the view that ApoER2-CTF exerts a modulatory role on reelin expression.-Mata-Balaguer, T., Cuchillo-Ibañez, I., Calero, M., Ferrer, I., Sáez-Valero, J. Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent11es_ES
dc.language.isoenges_ES
dc.publisherWiley Online Libraryes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectApoEes_ES
dc.subjectDNMT1es_ES
dc.subjectbraines_ES
dc.subjectmethylationes_ES
dc.titleDecreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer’s diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Neurocienciases_ES
dc.relation.publisherversionhttps://doi.org/10.1096/fj.201700736RRes_ES
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Instituto de Neurociencias


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