Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31148
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dc.contributor.authorFalco, Antonio-
dc.contributor.authorCHICO GRAS, VERONICA-
dc.contributor.authorMarroquí, L.-
dc.contributor.authorPerez, L.-
dc.contributor.authorColl, J.M.-
dc.contributor.authorEstepa, A.-
dc.date.accessioned2024-02-06T12:13:30Z-
dc.date.available2024-02-06T12:13:30Z-
dc.date.created2007-06-
dc.identifier.citationMolecular Immunology Volume 45, Issue 3, February 2008, Pages 757-765es_ES
dc.identifier.issn0161-5890-
dc.identifier.urihttps://hdl.handle.net/11000/31148-
dc.description.abstractThe in silico identification of a β-defensin-like peptide sequence (omBD-1) in the rainbow trout (Oncorhynchuss mykiss) database of salmonid EST is reported here. We have studied the transcript expression of this β-defensin-like sequence in different organs and expressed the recombinant peptide in a fish cell line. Finally, we have demonstrated the in vitro antiviral activity of the recombinant trout β-defensin-like peptide against viral haemorrhagic septicaemia rhabdovirus (VHSV), one of the most devastating viruses for worldwide aquaculture. Thus, the resistance to VHSV infection of EPC cells transfected with pMCV 1.4-omBD-1 has been shown. Since EPC cells transfected with omBD-1 produced acid and heat stable antiviral activity and up regulation of Mx, a type I IFN-mediated mechanism of antiviral action is suggested. To our knowledge, this is the first report showing biological activity of a β-defensin-like peptide from any fish.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent9es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntimicrobiales_ES
dc.subjectDefensines_ES
dc.subjectVHSVes_ES
dc.subjectIFNes_ES
dc.subjectMxes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::573 - Biología general y teóricaes_ES
dc.titleExpression and antiviral activity of a β-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequenceses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elchees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.molimm.2007.06.358es_ES
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Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche


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