Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31147
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dc.contributor.authorCHICO GRAS, VERONICA-
dc.contributor.authorMartinez-Lopez, A.-
dc.contributor.authorOrtega-Villaizan, Maria del Mar-
dc.contributor.authorFalco, Antonio-
dc.contributor.authorPerez, L.-
dc.contributor.authorColl, J. M.-
dc.contributor.authorEstepa, A.-
dc.date.accessioned2024-02-06T12:13:13Z-
dc.date.available2024-02-06T12:13:13Z-
dc.date.created2010-07-
dc.identifier.issn1098-5514-
dc.identifier.issn0022-538X-
dc.identifier.urihttps://hdl.handle.net/11000/31147-
dc.description.abstractSurface glycoproteins of enveloped virus are potent elicitors of type I interferon (IFN)-mediated antiviral responses in a way that may be independent of the well-studied genome-mediated route. However, the viral glycoprotein determinants responsible for initiating the IFN response remain unidentified. In this study, we have used a collection of 60 synthetic 20-mer overlapping peptides (pepscan) spanning the full length of glycoprotein G (gpG) of viral hemorrhagic septicemia virus (VHSV) to investigate what regions of this protein are implicated in triggering the type I IFN-associated immune responses. Briefly, two regions with ability to increase severalfold the basal expression level of the IFN-stimulated mx gene and to restrict the spread of virus among responder cells were mapped to amino acid residues 280 to 310 and 340 to 370 of the gpG protein of VHSV. In addition, the results obtained suggest that an interaction between VHSV gpG and integrins might trigger the host IFN-mediated antiviral response after VHSV infection. Since it is known that type I IFN plays an important role in determining/modulating the protective-antigen-specific immune responses, the identification of viral glycoprotein determinants di-rectly implicated in the type I IFN induction might be of special interest for designing new adjuvants and/or more-efficient and cost-effective viral vaccines as well as for improving our knowledge on how to stimulate the innate immune system.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiologyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecthemorrhagic septicemia viruses_ES
dc.subjectIFN-stimulated mx genees_ES
dc.subjectprotein are implicated in triggering the type I IFN-associated immune responseses_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::573 - Biología general y teóricaes_ES
dc.titlePepscan Mapping of Viral Hemorrhagic Septicemia Virus Glycoprotein G Major Lineal Determinants Implicated in Triggering Host Cell Antiviral Responses Mediated by Type I Interferones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elchees_ES
dc.relation.publisherversionhttps://doi.org/10.1128/jvi.00023-10es_ES
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Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche


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