Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30957
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dc.contributor.authorRibes, Sandra-
dc.contributor.authorRiegelmann, Jörn-
dc.contributor.authorRedlich, Sandra-
dc.contributor.authorMaestro García-Donas, Beatriz-
dc.contributor.authorde Waal, Bas-
dc.contributor.authorMeijer, E.W.-
dc.contributor.authorSanz, Jesús M.-
dc.contributor.authorNau, Roland-
dc.date.accessioned2024-02-02T09:41:42Z-
dc.date.available2024-02-02T09:41:42Z-
dc.date.created2013-
dc.identifier.citationChemotherapy . 2013;59(2):138-42.es_ES
dc.identifier.issn0009-3157-
dc.identifier.urihttps://hdl.handle.net/11000/30957-
dc.description.abstractBackground: Pneumococcal virulence factors common to all serotypes, such as choline-binding proteins (CBPs), are promising therapeutic targets in pneumococcal infections. We studied the effect of a choline dendrimer with maximized binding affinity/specificity for CBPs on microglia-mediated pneumococcal phagocytosis. Methods: Pneumoccocal cultures were exposed to dendrimers containing 8 choline end groups or amino groups as controls, either from the beginning of bacterial growth or at the late exponential phase. The effect of long/short co-incubation was assessed in terms of bacterial morphological changes and increase in bacterial uptake by primary microglial cultures. Results: Inhibiting CBPs by micromolar concentrations of a choline dendrimer caused the formation of long pneumococcal chains that were readily phagocytosed by microglia. Enhanced phagocytosis was dendrimer dose-dependent. Long bacteria-dendrimer co-incubation (14 h) resulted in a higher bacterial uptake than short co-incubation (2 h; p < 0.001). Conclusions: Multivalent dendrimers containing choline end groups are promising antimicrobial agents for the management of pneumococcal diseases.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent5es_ES
dc.language.isoenges_ES
dc.publisherS. Karger AG, Baseles_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCholine-binding proteinses_ES
dc.subjectStreptococcus pneumoniaees_ES
dc.subjectDendrimeres_ES
dc.subjectPhagocytosises_ES
dc.subjectMicrogliaes_ES
dc.titleMultivalent Choline Dendrimers Increase Phagocytosis of Streptococcus pneumoniae R6 by Microglial Cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Bioingenieríaes_ES
dc.relation.publisherversionhttps://doi.org/10.1159/000353439es_ES
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